Novel algorithm for background correction of the quantitative spectroscopic tomography of the biogenic-substances
Novel algorithm for background correction of the quantitative spectroscopic tomography of the biogenic-substances
复制标题
生物物质定量光谱断层扫描背景校正的新算法
DOI：
10.1117/12.2003402
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
I. Ishimaru
中科院分区：
文献类型：
--
作者：
P. Abeygunawardhana;W. Qi;D. Kojima;Satoru Suzuki;A. Nishiyama;I. Ishimaru
本研究将利用影像式二维傅立叶光谱技术来实现非侵入式血糖感测器。通过暗场图像观察生物组织的分光成像可以定量地测量诸如葡萄糖浓度的生物物质。对于高精度的定量分析，背景校正如光源波动和相移不确定性是不可避免的问题。因此，已经由[1]提出了在其上局部形成光栅的定量带通板。在该论文中，衍射光，其衍射角取决于波长，已被用作参考光。利用物镜透镜对参考光进行窄化处理，得到窄带通衍射光。利用定量带通滤波器可以确认观察图像的整个区域上的具有干涉现象的成像强度的变化。提出了光谱层析成像中干涉图的背景校正方法。校正算法主要包括光源波动误差校正和相移误差校正两部分。
The non-invasive blood sugar sensor by using imaging-type 2-dimensional Fourier spectroscopy is to be realized in this work. The spectroscopic imaging, that observes the biological tissue by the dark-field image, can measure the biogenic substance quantitatively such as the glucose concentration. For the quantitative analysis with high accuracy, the correction of the background such as the light-source fluctuation and the phase-shift uncertainty is inevitable issue. Thus, the quantitative band-pass plate on which the grating is locally formed has been already proposed by [1]. In that paper, the diffractive light, whose diffraction angle depends on the wavelength, has been used as the reference light. Object lens is used to narrow down the reference light and narrowed band pass diffraction light is obtained. The changes of imaging intensities with interference phenomenon on whole area of the observation image can be confirmed using the quantitative band pass filter. This paper proposed background correction method of the interferogram in spectroscopic tomography. Correction algorithm mainly contained two parts as light source fluctuation error correction and phase shift error correction.