Modulation of apolipoprotein c-iii (apociii) expression in lipoprotein lipase deficient (lpld) populations
Modulation of apolipoprotein c-iii (apociii) expression in lipoprotein lipase deficient (lpld) populations
复制标题
脂蛋白脂肪酶缺陷 (lpld) 群体中载脂蛋白 c-iii (apociii) 表达的调节
DOI：
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发表时间：
2014
期刊：
影响因子：
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通讯作者：
Джозеф Л. Уитзтум
中科院分区：
文献类型：
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作者：
Вероника Дж. Александер;Николас Дж. Виней;Джозеф Л. Уитзтум
领域:生物技术。实质：拟议的一组发明与生物技术有关。使用一个特定的ApoCIII抑制剂组成的反义复合目标ApoCIII抑制ApoCIII的表达式提出了我)治疗,减缓或促进FCS在动物或ii)放缓或减轻胰腺炎或其症状与FCS的动物,还使用一个化合物组成的修改寡核苷酸序列为SEQ ID没有:3,治疗,减缓或执行FCS在动物和减缓或缓解胰腺炎或其症状与FCS的动物。效果：建议使用这些ApoCIII抑制剂，抑制ApoCIII的表达，导致受试者TG水平降低和/或HDL水平升高，从而提供治疗，减缓或减轻动物FCS，或减缓或减轻FCS动物的胰腺炎。24毫升，10毫升，1毫升
FIELD: biotechnology. SUBSTANCE: proposed group of inventions relates to biotechnology. Use of a specific ApoCIII inhibitor comprising an antisense compound targeting ApoCIII inhibiting the expression of ApoCIII is proposed for i) treating, slowing or facilitating FCS in an animal or ii) slowing or alleviating pancreatitis or its symptom in an animal with FCS, also using a compound comprising a modified oligonucleotide of the sequence of SEQ ID NO: 3, to treat, slow or enforce FCS in an animal and to slow or alleviate pancreatitis or its symptom in an animal with FCS. EFFECT: proposed use of these ApoCIII inhibitors that inhibit the expression of ApoCIII lead to a reduction in TG levels and / or an increase in HDL levels in the subject, thereby providing treatment, slowing or alleviating FCS in an animal, or slowing or alleviating pancreatitis in an animal with FCS. 24 cl, 10 tbl, 1 ex