A new flavonol glycoside gallate ester from Acer okamotoanum and its inhibitory activity against human immunodeficiency virus-1 (HIV-1) integrase
A new flavonol glycoside gallate ester from Acer okamotoanum and its inhibitory activity against human immunodeficiency virus-1 (HIV-1) integrase
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DOI：
10.1021/np970171q
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发表时间：
1998-01-01
影响因子：
5.1
通讯作者：
Park, H
中科院分区：
文献类型：
--
作者：
Kim, HJ;Woo, ER;Park, H
用HIV-1整合酶对冈本槭叶的乙酸乙酯提取物进行生物测定导向色谱分离，得到一种新的酰化黄酮醇糖苷，槲皮素3-0-（2“，6“-0-二别戊酰基）-β-D-半乳吡喃（1），以及六种已知的黄酮醇糖苷和三种已知的酚类化合物。新化合物的结构用光谱法测定。最具活性的化合物是槲皮素3-O-（2“-没食子酰基）-α-L-阿拉伯吡喃糖苷（6）和1，其对HIV-1整合酶的IC 50值分别为18.1 +/- 1.3和24.2 +/- 6.6 μ g/mL。
Bioassay-directed chromatographic fractionation of an ethyl acetate extract of the leaves of Acer okamotoanum using HIV-1 integrase afforded a new acylated flavonol glycoside, quercetin 3-0-(2 ",6 "-0-digalloyl)-beta-D-galactopyra (1), together with six known flavonol glycosides and three known phenolic compounds. The structure of the new compound was determined by spectroscopic methods. The most active compounds were quercetin 3-O-(2 "-galloyl)-alpha-L-arabinopyranoside (6) and 1, which exhibited IC50 values of 18.1 +/- 1.3 and 24.2 +/- 6.6 mu g/mL, respectively, against HIV-1 integrase.