FoxN3 is necessary for the development of the interatrial septum, the ventricular trabeculae and the muscles at the head/trunk interface in the African clawed frog, Xenopus laevis (Lissamphibia: Anura: Pipidae)
FoxN3 is necessary for the development of the interatrial septum, the ventricular trabeculae and the muscles at the head/trunk interface in the African clawed frog, Xenopus laevis (Lissamphibia: Anura: Pipidae)
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DOI：
10.1002/dvdy.25
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发表时间：
2019-03
影响因子：
2.5
通讯作者：
Benjamin Naumann;Jennifer Schmidt;L. Olsson
中科院分区：
文献类型：
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作者：
Benjamin Naumann;Jennifer Schmidt;L. Olsson
Fox基因是一个转录因子大家族，在免疫系统、代谢、癌症、细胞周期和动物发育中发挥着不同的作用。研究表明，FoxN3对于小鼠和非洲爪蟾（Xenopus laevis）的正常颅面发育是必不可少的。在X. laevis会延迟早期蝌蚪阶段的整体发育，并导致眼睛缺陷、某些颅神经分支缺失以及颅骨骼和某些颅肌肉畸形，而躯干的骨骼、神经和肌肉则不受影响。
Fox genes are a large family of transcription factors that play diverse roles in the immune system, metabolism, cancer, cell cycle, and animal development. It has been shown that FoxN3 is indispensable for normal craniofacial development in the mouse and the African clawed frog, Xenopus laevis. Morpholino‐mediated knockdown of FoxN3 in X. laevis delays overall development of early tadpole stages and causes eye defects, the absence of some cranial nerve branches, and malformations of the cranial skeleton and some cranial muscles, while the skeleton, nerves and muscles of the trunk are unaffected.