LOW INCIDENCE OF NULL ALLELES OF THE 4TH COMPONENT OF COMPLEMENT (C-4) IN ELDERLY PEOPLE
LOW INCIDENCE OF NULL ALLELES OF THE 4TH COMPONENT OF COMPLEMENT (C-4) IN ELDERLY PEOPLE
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DOI：
10.1016/0165-2478(89)90073-4
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发表时间：
1989-01-15
影响因子：
4.4
通讯作者：
FUST, G
中科院分区：
文献类型：
--
作者：
KRAMER, J;RAJCZY, K;FUST, G
在150名“年轻人”（53岁以下）和131名“老年人”（62岁以上）健康匈牙利人中检测了第六染色体上编码的三种补体蛋白（C2、因子B和C4）的同种异型频率。在女性中，我们发现两个年龄组之间BF*F同种异型频率存在显著差异。观察到C4无效等位基因显着减少，尤其是在男性中。在“老年”年龄组中，C4蛋白的未表达的“无效”（Q 0）等位基因的总频率下降到“年轻”等位基因的近三分之一。男性的下降幅度更大（发病率下降5.5倍）。具有C_4B * Q_0等位基因的人在53-62岁男性和58-62岁女性的“关键年龄期”内不能存活的相对危险度分别为12.4和2.85。我们的数据证实了预期寿命是由遗传决定的观点，并且可以通过分析第六染色体上编码的抗原来部分预测。
Allotype frequencies of three complement proteins (C2, factor B, and C4) encoded on the sixth chromosome were tested in 150 "young" (under 53 yrs) and 131 "old" (over 62 yrs) healthy Hungarian individuals. In women, we found significant differences in BF*F allotype freqencies between the two age groups. A marked decrease of null alleles for C4 was observed especially in men. In the "old" age group, the total frequency of the non-expressed, "null" (Q0) alleles of the C4 protein dropped to almost one third of the "young" ones. The decrease was even larger (a 5.5-fold decrease in the incidence) among men. The relative risk of those having C4B*Q0 allele not to survive a "critical age period" of 53-62 yrs for males and 58-62 yrs for females was calculated to be 12.4 and 2.85, respectively. Our data substantiate the view that the expected life time is genetically determined and it can be forecast partly by the analysis of the antigens encoded on the sixth chromosome.