GLIDING MOTILITY AND THE DYNAMICS OF FLAGELLAR MEMBRANE-GLYCOPROTEINS IN CHLAMYDOMONAS-REINHARDTII
GLIDING MOTILITY AND THE DYNAMICS OF FLAGELLAR MEMBRANE-GLYCOPROTEINS IN CHLAMYDOMONAS-REINHARDTII
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DOI：
10.1111/j.1550-7408.1988.tb04151.x
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发表时间：
1988-11-01
期刊：
影响因子：
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通讯作者：
BLOODGOOD, RA
中科院分区：
文献类型：
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作者：
BLOODGOOD, RA
在大多数原生生物以及大多数后生动物运动配子中，纤毛和鞭毛的功能似乎很明显：由弯曲的协调启动和传播引起的全细胞游泳运动的产生。在后生动物中，纤毛在纤毛上皮上的协调活动导致水、粘液或配子沿着上皮的自由表面运动。纤毛和鞭毛的弯曲运动源自其高度特化的细胞骨架，称为轴丝 (1 9)。事实上，脱膜和清洗的纤毛和鞭毛轴丝可以被重新激活以表现出基本正常的运动模式（19），这导致多年来人们对纤毛和鞭毛表面缺乏关注。然而，近年来，人们越来越清楚，纤毛和鞭毛膜对真核细胞具有许多重要的功能，包括通过钙动作电位进行信号传输 (32)、海洋无脊椎动物对固体基质的锚定 (50)、寄生原生动物与昆虫宿主肠道内壁的结合 (1 3, 30)、全细胞滑行运动 (4)、纤毛虫原生动物的交配相互作用 (3 1, 52) 和藻类鞭毛虫 (1, 5 I)，以及嗅觉上皮中气味受体的位置 (4 1)。大多数这些功能独立于正常的弯曲运动，并且与纤毛或鞭毛膜糖蛋白相关。对于各种历史和技术
In most protists, as well as in most metazoan motile gametes, the function of cilia and flagella seems obvious: the production of whole cell swimming movements brought about by the coordinated initiation and propagation of bends. In metazoa, the coordinated activity of cilia on ciliated epithelia results in the movement of water, mucus, or gametes along the free surface ofan epithelium. The bending motility ofcilia and flagella arises from their highly specialized cytoskeleton, referred to as the axoneme (1 9). Indeed, the demonstration that demembranated and washed ciliary and flagellar axonemes can be reactivated to exhibit essentially normal patterns of motility (19) led for years to a lack of attention being paid to ciliary and flagellar surfaces. In recent years, however, it has become clear that ciliary and flagellar membranes perform many important functions for eukaryotic cells including signal transmission via a calcium action potential (32), anchorage of marine invertebrates to solid substrates (50), binding of parasitic protozoa to the gut lining of the insect host (1 3, 30), whole cell gliding movements (4), mating interactions in ciliate protozoa (3 1, 52) and algal flagellates (1, 5 I), and the location of odorant receptors in the olfactory epithelium (4 1). Most of these functions are independent of normal bending motility and are associated with ciliary or flagellar membrane glycoproteins. For a variety of historical and tech-