Effect of variation in intraluminal thrombus constitutive properties on abdominal aortic aneurysm wall stress
Effect of variation in intraluminal thrombus constitutive properties on abdominal aortic aneurysm wall stress
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DOI：
10.1114/1.1581880
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发表时间：
2003-07-01
影响因子：
3.8
通讯作者：
Vorp, DA
中科院分区：
文献类型：
--
作者：
Di Martino, ES;Vorp, DA
腹主动脉瘤（AAA）是一种退行性疾病，其终末期是血管壁破裂。作用在动脉瘤组织上的应力的准确预测可用于确定特定动脉瘤破裂的实际风险。为了实现这一点，需要一个正确的主动脉壁和任何腔内血栓（ILT）内存在的本构模型。我们的实验室以前曾报道过ILT的机械性能。本研究的目的是探讨使用总体平均值的ILT本构参数来估计AAA壁应力分布的可靠性。为此，生成了包括ILT的动脉瘤的三维非对称模型，并进行了参数研究，在生理范围内改变ILT的组成特性。结果表明，任何ILT的存在下，主动脉壁的应力显着减少和重新分布。所有分析模型的峰值壁应力的最大变化为5%。采用非均匀ILT并不改变应力分布。基于这些结果，我们推断ILT材料特性的总体平均参数可用于合理估计患者特定动脉瘤模型中的壁应力。(C)2003生物医学工程学会。
The abdominal aortic aneurysm (AAA) is a degenerating disease for which the end stage is the rupture of the vessel wall. Accurate prediction of the stresses acting on the aneurysm tissue may be used to determine the actual risk of rupture of a specific aneurysm. To accomplish this, a correct constitutive model for the aneurysmal aortic wall and any intraluminal thrombus (ILT) present within it are needed. Our laboratory has previously reported the mechanical properties of ILT. The aim of this work is to investigate the reliability of using population-mean values of ILT constitutive parameters to estimate AAA wall stress distribution. For this, a three-dimensional asymmetric model of an aneurysm including ILT was generated and a parametric study was conducted varying ILT constitutive properties within a physiological range. Results show that the presence of any ILT reduces and redistributes the stresses in the aortic wall markedly. Maximum variation in the peak wall stresses for all the models analyzed was 5%. Adopting a nonhomogeneous ILT did not alter the stress distribution. On the basis of these results, we infer that population mean parameters for ILT material characteristics can be used to reasonably estimate the wall stresses in patient specific aneurysm models. (C) 2003 Biomedical Engineering Society.