Topical instillation of ciliary neurotrophic factor inhibits retinal degeneration in streptozotocin-induced diabetic rats
Topical instillation of ciliary neurotrophic factor inhibits retinal degeneration in streptozotocin-induced diabetic rats
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DOI：
10.1097/00001756-200311140-00012
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发表时间：
2003-11-14
期刊：
影响因子：
1.7
通讯作者：
Oyanagi, K
中科院分区：
文献类型：
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作者：
Aizu, Y;Katayama, H;Oyanagi, K
眼内注射睫状神经营养因子（CNTF）或眼内腺病毒介导的CNTF基因转移已被报道可抑制小鼠遗传性视网膜变性的视网膜改变。为了研究通过滴眼液施用CNTF是否预防链脲佐菌素（STZ）诱导的糖尿病大鼠的视网膜变性，在糖尿病发作后，将重组CNTF施用于糖尿病大鼠（n=20）的眼睛，每天两次，持续1个月。CNTF组大鼠视网膜电图b波振幅明显大于糖尿病组，接近对照组。在糖尿病大鼠中观察到的内丛状层萎缩和色素上皮空洞形成在给予CNTF的糖尿病大鼠中得到了预防。这些结果表明，CNTF的滴眼液管理预防视网膜变性STZ诱导的糖尿病大鼠。
Intraocular injections of ciliary neurotrophic factor (CNTF) or intraocular adenovirus-mediated CNTF gene transfer have been reported to inhibit retinal alterations in inherited retinal degeneration in mice strains. To investigate whether or not CNTF administered by eye drops prevents retinal degeneration in streptozotocin (STZ)-induced diabetic rats, recombinant CNTF was administered to eyes of diabetic rats (n=20) twice daily for 1 month after the onset of diabetes. The b-wave amplitude of electroretinogram in CNTF-administered diabetic rats was significantly larger than that of diabetic rats, and approached that of the controls. Atrophy of the inner plexiform layer, and cavity formation in the pigment epithelium, which were observed in diabetic rats, were prevented in CNTF-administered diabetic rats. These results indicate that CNTF administration by eye drops prevents retinal degeneration in STZ-induced diabetic rats.