The National Consortium on Alcohol and Neuro-Development in Adolescence (NCANDA): A Multisite Study of Adolescent Development and Substance Use
The National Consortium on Alcohol and Neuro-Development in Adolescence (NCANDA): A Multisite Study of Adolescent Development and Substance Use
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DOI：
10.15288/jsad.2015.76.895
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发表时间：
2015-11-01
影响因子：
3.4
通讯作者：
Tapert, Susan F.
中科院分区：
文献类型：
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作者：
Brown, Sandra A.;Brumback, T. Y.;Tapert, Susan F.
目标：在青春期，神经生物学成熟与社会和人际变化同时发生，包括开始使用酒精和其他物质。国家酒精和青少年神经发育联盟（NCANDA）旨在解开酒精使用的发作，升级和停止与神经认知功能和神经成熟变化之间的复杂关系。方法：在美国的五个地点招募了831名年龄在12-21岁之间的青少年，对那些有酒精使用问题风险的人进行了过度抽样。大多数人（83%）有有限或没有饮酒或其他药物使用史，一小部分人（17%）超过了饮酒阈值。在基线时完成对生物发育、家庭背景、精神病学和神经心理功能的综合评估，以及解剖、弥散和功能性脑磁共振成像。结果：NCANDA青年样本在性别和种族/族裔群体方面具有全国代表性。超过50%的人至少有一个随后大量饮酒的风险特征（例如，家族史、内在或外在症状）。正如预期的那样，那些超过饮酒阈值的人（n = 139）与那些没有饮酒阈值的人（n = 692）在与早期饮酒和问题相关的确定因素上存在差异。结论：NCANDA成功招募了大量青少年样本，并全面评估了多个领域的心理社会功能。根据样本的风险状况，NCANDA能够很好地捕捉到大部分队列中饮酒和酒精问题的转变，并帮助解开酒精使用，神经生物学成熟和神经认知发育和功能之间的关联。
Objective: During adolescence, neurobiological maturation occurs concurrently with social and interpersonal changes, including the initiation of alcohol and other substance use. The National Consortium on Alcohol and NeuroDevelopment in Adolescence (NCANDA) is designed to disentangle the complex relationships between onset, escalation, and desistance of alcohol use and changes in neurocognitive functioning and neuromaturation. Method: A sample of 831 youth, ages 12-21 years, was recruited at five sites across the United States, oversampling those at risk for alcohol use problems. Most (83%) had limited or no history of alcohol or other drug use, and a smaller portion (17%) exceeded drinking thresholds. A comprehensive assessment of biological development, family background, psychiatric symptomatology, and neuropsychological functioning-in addition to anatomical, diffusion, and functional brain magnetic resonance imaging-was completed at baseline. Results: The NCANDA sample of youth is nationally representative of sex and racial/ethnic groups. More than 50% have at least one risk characteristic for subsequent heavy drinking (e.g., family history, internalizing or externalizing symptoms). As expected, those who exceeded drinking thresholds (n = 139) differ from those who did not (n = 692) on identified factors associated with early alcohol use and problems. Conclusions: NCANDA successfully recruited a large sample of adolescents and comprehensively assessed psychosocial functioning across multiple domains. Based on the sample's risk profile, NCANDA is well positioned to capture the transition into drinking and alcohol problems in a large portion of the cohort, as well as to help disentangle the associations between alcohol use, neurobiological maturation, and neurocognitive development and functioning.