CXCL2, a new critical factor and therapeutic target for cardiovascular diseases
CXCL2, a new critical factor and therapeutic target for cardiovascular diseases
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DOI：
10.1080/10641963.2019.1693585
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发表时间：
2019-11-23
影响因子：
12.3
通讯作者：
Wang, Ai-Ping
中科院分区：
文献类型：
--
作者：
Guo, Lin-Ya;Yang, Fang;Wang, Ai-Ping
心血管疾病（CVD）是全球死亡的主要原因。研究表明，炎症趋化因子参与细胞骨架重组、细胞迁移、粘附和免疫反应等生理功能。然而，在过去的十年中，有研究表明炎症趋化因子在CVD中起着关键作用。重要的是，CXC基序趋化因子配体2（CXCL2）已被证明参与心血管疾病的发病机制。CXCL2通过介导炎症反应对心血管系统发挥作用，但CXCL2在CVD中发挥作用的具体信号通路仍然未知，需要进一步研究。本文就CXCL2在急性心肌梗死（AMI）、动脉粥样硬化（AS）、肥胖、糖尿病和缺血性脑卒中（IS）等心血管疾病中的表达变化及其潜在的关键作用进行综述，以期为心血管疾病的防治提供新的思路。
Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Previous studies have shown that inflammatory chemokines are involved in the physiological functions of cytoskeletal reorganization, cell migration, adhesion and immune responses. However, in the past decade, there have been studies showing that inflammatory chemokines play a key role in CVD. Importantly, CXC motif chemokine ligand 2 (CXCL2) has been shown to be involved in the pathogenesis of cardiovascular disease. CXCL2 exerts its effects on the cardiovascular system by mediating inflammatory responses, but the specific signaling pathways by which CXCL2 exerts its effects in CVD remain unknown and need to be further investigated. This review aims to investigate the expression changes of CXCL2 in acute myocardial infarction (AMI), atherosclerosis (AS), obesity, diabetes and ischemic stroke (IS) and its potential key role in cardiovascular disease in order to provide new ideas for the prevention and treatment of cardiovascular diseases.