Brain-Derived Neurotrophic Factor Signaling in the Pathophysiology of Alzheimer's Disease: Beneficial Effects of Flavonoids for Neuroprotection.
Brain-Derived Neurotrophic Factor Signaling in the Pathophysiology of Alzheimer's Disease: Beneficial Effects of Flavonoids for Neuroprotection.
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DOI：
10.3390/ijms22115719
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发表时间：
2021-05-27
影响因子：
5.6
通讯作者：
Odaka H
中科院分区：
文献类型：
--
作者：
Numakawa T;Odaka H
脑源性神经营养因子（BDNF）通过其高亲和力受体原肌球蛋白受体激酶B （TrkB）的激活，在中枢神经系统神经元的细胞分化、细胞存活、突触可塑性以及胚胎和成人神经发生中发挥关键作用。许多研究表明，BDNF/TrkB信号的表达和作用改变可能参与包括阿尔茨海默病（AD）在内的神经退行性疾病的发病机制。在这篇综述中，我们介绍了BDNF及其下游信号在神经功能中的重要作用。我们还从基因、mRNA和蛋白水平上回顾了目前关于阿尔茨海默病病理生理中BDNF信号失调的证据。此外，我们还讨论了包括类黄酮在内的小化合物的潜在用途，它们可以刺激bdnf相关的信号传导，作为bdnf靶向治疗。
The function of the brain-derived neurotrophic factor (BDNF) via activation through its high-affinity receptor Tropomyosin receptor kinase B (TrkB) has a pivotal role in cell differentiation, cell survival, synaptic plasticity, and both embryonic and adult neurogenesis in central nervous system neurons. A number of studies have demonstrated the possible involvement of altered expression and action of the BDNF/TrkB signaling in the pathogenesis of neurodegenerative diseases, including Alzheimer’s disease (AD). In this review, we introduce an essential role of the BDNF and its downstream signaling in neural function. We also review the current evidence on the deregulated the BDNF signaling in the pathophysiology of AD at gene, mRNA, and protein levels. Further, we discuss a potential usefulness of small compounds, including flavonoids, which can stimulate BDNF-related signaling as a BDNF-targeting therapy.
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影响因子：
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作者：
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通讯作者：
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