Sex-based differences in the tensile properties of the human anterior cruciate ligament
Sex-based differences in the tensile properties of the human anterior cruciate ligament
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DOI：
10.1016/j.jbiomech.2005.10.031
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发表时间：
2006-01-01
影响因子：
2.4
通讯作者：
Hashemi, Javad
中科院分区：
文献类型：
--
作者：
Chandrashekar, Naveen;Mansouri, Hossein;Hashemi, Javad
经过大量的研究，女性前交叉韧带（ACL）故障事件发生率显著高于男性的根本原因仍然未知，现有的性别差异并没有减少。迄今为止，尚未直接研究女性ACL在机械上弱于男性ACL的可能性。尽管文献中已确定女性ACL尺寸较小，但尚未研究性别之间ACL的结构和材料特性差异。该尸体研究的目的是确定当考虑年龄以及ACL和人体测量作为协变量时，人类ACL的拉伸性能是否存在任何基于性别的差异。本研究使用了10例男性和10例女性未配对尸体膝关节（平均年龄36.75岁）。使用三维扫描系统分析ACL的几何形状（包括长度、横截面积和体积）。在拉伸试验机中沿韧带纵轴沿着测试股骨-ACL胫骨复合体失效。ACL的结构特性以及其机械性能进行了测定。进行协方差分析，以评估性别对拉伸性能的影响。当考虑年龄、ACL和人体测量作为协变量时，发现女性ACL的机械性能较低（失效应变低8.3%;失效应力低14.3%，失效应变能密度低9.43%，最重要的是，弹性模量低22.49%）。(c)2005爱思唯尔有限公司保留所有权利。
After immense amounts of research, the root cause for the significantly higher rates of anterior cruciate ligament (ACL) failure incidents in females as compared to males still remains unknown and the existing sex-based disparity has not diminished. To date, the possibility that the female ACL is mechanically weaker than the male ACL has not been directly investigated. Although it has been established in the literature that the female ACL is smaller in size, the differences in the structural and material properties of the ACL between sexes have not been studied. The aim of this cadaveric study was to determine if any sex-based differences in the tensile properties of the human ACL exist when considering age as well as ACL and body anthropometric measurements as covariates. Ten male and 10 female unpaired cadaveric knees (mean age 36.75 years) were used for this study. The geometry of the ACL (including length, cross-sectional area, and volume) was analyzed using a 3-D scanning system. The femur-ACL tibia complex was tested to failure along the longitudinal axis of the ligament in a tensile testing machine. The structural properties of the ACL as well as its mechanical properties were determined. Analysis of covariance was performed to assess the effect of sex on tensile properties. The female ACL was found to have a lower mechanical properties (8.3% lower strain at failure; 14.3% lower stress at failure, 9.43% lower strain energy density at failure, and most importantly, 22.49% lower modulus of elasticity) when considering age, ACL, and body anthropometric measurements as covariates. (c) 2005 Elsevier Ltd. All rights reserved.