Reference Intervals for Brachial Artery Flow-Mediated Dilation and the Relation With Cardiovascular Risk Factors
Reference Intervals for Brachial Artery Flow-Mediated Dilation and the Relation With Cardiovascular Risk Factors
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DOI：
10.1161/hypertensionaha.120.15754
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发表时间：
2021-05-01
期刊：
影响因子：
8.3
通讯作者：
Thijssen, Dick H. J.
中科院分区：
文献类型：
--
作者：
Holder, Sophie M.;Bruno, Rosa Maria;Thijssen, Dick H. J.
使用肱动脉血流介导的舒张（FMD）评估内皮功能，可预测未来心血管疾病（CVD）风险。本研究建立了健康个体肱动脉FMD的年龄和性别特异性参考区间，并研究了与CVD危险因素的关系。在一项回顾性研究设计中，我们汇总了5362名个体（4-84岁; 2076名女性）的肱动脉FMD（根据FMD方案和分析的专家共识指南采集）和参与者特征/病史。使用健康个体（n=1403 [582名女性]）生成年龄/性别特异性百分位数曲线。随后，我们纳入了有CVD风险因素的个体，没有明显的疾病（未用药n=3167 [1247名女性]和用药n=792 [247名女性]）。多元线性回归测试CVD危险因素（体重指数、血压、胆固醇、糖尿病、血脂异常和吸烟）与FMD的关系。健康的男性表现出一个负的，曲线关系之间的FMD和年龄，而女性揭示了一个负的线性关系，开始更高，但下降速度比男性。FMD的年龄和性别特异性差异至少部分与基线动脉直径有关。FMD与未用药个体（如收缩压/舒张压）和用药个体（如糖尿病/血脂异常）的CVD危险因素相关。性别介导了其中的一些效应（P
Endothelial function, assessed using brachial artery flow-mediated dilation (FMD), predicts future cardiovascular disease (CVD) risk. This study established age- and sex-specific reference intervals for brachial artery FMD in healthy individuals and examined the relation with CVD risk factors. In a retrospective study design, we pooled brachial artery FMD (acquired according to expert-consensus guidelines for FMD protocol and analysis) and participant characteristics/medical history from 5362 individuals (4-84 years; 2076 females). Healthy individuals (n=1403 [582 females]) were used to generate age-/sex-specific percentile curves. Subsequently, we included individuals with CVD risk factors, without overt disease (unmedicated n=3167 [1247 females] and medicated n=792 [247 females]). Multiple linear regression tested the relation of CVD risk factors (body mass index, blood pressure, cholesterol, diabetes, dyslipidemia, and smoking) with FMD. Healthy males showed a negative, curvilinear relation between FMD and age, while females revealed a negative linear relation that started higher but declined at a faster rate than males. Age- and sex-specific differences in FMD relate, at least partly, to baseline artery diameter. FMD was related to CVD risk factors in unmedicated (eg, systolic/diastolic blood pressure) and medicated individuals (eg, diabetes/dyslipidemia). Sex mediated some of these effects (P