Effects of ACE2 inhibition in the post-myocardial infarction heart.
Effects of ACE2 inhibition in the post-myocardial infarction heart.
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DOI：
10.1016/j.cardfail.2010.04.002
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发表时间：
2010-09
影响因子：
6
通讯作者：
Greenberg, Barry
中科院分区：
文献类型：
--
作者：
Kim, Myung-A;Yang, Dongheon;Kida, Keisuke;Molotkova, Natalia;Yeo, Seon Ju;Varki, Nissi;Iwata, Michikado;Dalton, Nancy D.;Peterson, Kirk L.;Siems, Wolf-Eberhard;Walther, Thomas;Cowling, Randy T.;Kjekshus, John;Greenberg, Barry
关键词：
有证据表明，血管紧张素转换酶2（ACE 2）是心脏保护。为了在心肌梗死（MI）后心脏中评估这一点，我们在永久性冠状动脉结扎或假手术后用安慰剂（PL）或C16（一种选择性ACE 2抑制剂）治疗成年雄性Sprague-Dawley大鼠。冠状动脉结扎导致25-50%的左心室（LV）周长之间的MI，导致实质性心脏重塑。从术后第2天至第28天，以抑制心肌ACE 2活性的剂量每日给予C16与MI尺寸显著增加和LV缩短百分比降低相关。C16治疗对MI后LV舒张末期尺寸的增加无显著影响，但可抑制非梗死LV的壁厚和纤维化增加。在术后第7天，C16对梗死区和边缘区细胞凋亡水平的增加没有显著影响，也没有显著影响MI周围的毛细血管密度。然而，它确实显著减少了边缘区域的c-kit+细胞数量。这些发现支持了ACE 2通过保护边缘区受损的心肌细胞而发挥心脏保护作用的观点。然而，C16的肥大和纤维化减少表明ACE 2活性对MI后重塑具有不同的影响。
There is evidence that angiotensin-converting enzyme 2 (ACE2) is cardioprotective. To assess this in the post-myocardial infarction (MI) heart, we treated adult male Sprague-Dawley rats with either placebo (PL) or C16, a selective ACE2 inhibitor, following permanent coronary artery ligation or sham operation. Coronary artery ligation resulting in MI between 25–50% of the left ventricular (LV) circumference caused substantial cardiac remodeling. Daily C16 administration from post-operative days 2 to 28 at a dose that inhibited myocardial ACE2 activity was associated with a significant increase in MI size and reduction in LV % fractional shortening. Treatment with C16 did not significantly affect post-MI increases in LV end-diastolic dimension but did inhibit increases in wall thickness and fibrosis in non-infarcted LV. On post-operative day 7, C16 had no significant effect on the increased level of apoptosis in the infarct and border zones nor did it significantly affect capillary density surrounding the MI. It did, however, significantly reduce the number of c-kit+ cells in the border region. These findings support the notion that ACE2 exerts cardioprotective effects by preserving jeopardized cardiomyocytes in the border zone. The reduction in hypertrophy and fibrosis with C16, however, suggests that ACE2 activity has diverse effects on post-MI remodeling.
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影响因子：
24
作者：
Epelman, Slava;Tang, W. H. Wilson;Chen, Stephen Y.;Van Lente, Frederick;Francis, Gary S.;Sen, Subha
通讯作者：
Sen, Subha
影响因子：
5
作者：
Gurantz, D;Cowling, RT;Greenberg, BH
通讯作者：
Greenberg, BH
影响因子：
15
作者：
Dales, NA;Gould, AE;Patane, MA
通讯作者：
Patane, MA
影响因子：
37.8
作者：
GREENBERG, B;QUINONES, MA;SHELTON, B
通讯作者：
SHELTON, B
心肌梗塞会增加大鼠和人类 ACE2 的表达
影响因子：
39.3
作者：
Burrell, LM;Risvanis, J;Johnston, CI
通讯作者：
Johnston, CI