Mechanisms underlying the formation of the amygdalar fear memory trace: A computational perspective.
Mechanisms underlying the formation of the amygdalar fear memory trace: A computational perspective.
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DOI：
10.1016/j.neuroscience.2016.02.059
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发表时间：
2016-05-13
期刊：
影响因子：
3.3
通讯作者：
Nair SS
中科院分区：
文献类型：
--
作者：
Feng F;Samarth P;Paré D;Nair SS
最近的实验和建模研究表明，杏仁核（LA）的内在兴奋性和竞争性突触之间的相互作用的主要神经元（PN）的听觉恐惧记忆的形成。目前的建模研究，在网络中的内在兴奋性的扩大范围内进行，揭示了只有兴奋性PN的音调输入参与竞争。引人注目的是，尽管考虑的范围大得多，但整合到恐惧记忆痕迹中的模型PN的数量保持不变，并且模型运行突出了各种PN人群的几个条件诱导的音调响应特征。此外，这些研究表明，虽然兴奋是重要的，双突触抑制之间的PN是占主导地位的机制，保持塑料PN的数量稳定，尽管在网络的兴奋性大的变化。最后，我们发现模型网络中的总体抑制水平决定了整合到恐惧记忆痕迹中的投射细胞的数量。
Recent experimental and modeling studies on the lateral amygdala (LA) have implicated intrinsic excitability and competitive synaptic interactions among principal neurons (PNs) in the formation of auditory fear memories. The present modeling studies, conducted over an expanded range of intrinsic excitability in the network, revealed that only excitable PNs that received tone inputs participate in the competition. Strikingly, the number of model PNs integrated into the fear memory trace remained constant despite the much larger range considered, and model runs highlighted several conditioning-induced tone responsive characteristics of the various PN populations. Furthermore, these studies showed that although excitation was important, disynaptic inhibition among PNs is the dominant mechanism that keeps the number of plastic PNs stable despite large variations in the network's excitability. Finally, we found that the overall level of inhibition in the model network determines the number of projection cells integrated into the fear memory trace.