The Role of Hexokinase Domain Containing Protein-1 in Glucose Regulation During Pregnancy.
The Role of Hexokinase Domain Containing Protein-1 in Glucose Regulation During Pregnancy.
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DOI：
10.1007/s11892-021-01394-4
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发表时间：
2021-07-07
影响因子：
4.2
通讯作者：
Layden BT
中科院分区：
文献类型：
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作者：
Zapater JL;Lednovich KR;Layden BT
妊娠期糖尿病（GDM）是一种常见的妊娠并发症，其增加了个体发展为2型糖尿病的风险。因此，有必要彻底了解GDM的病理生理学。己糖激酶结构域蛋白-1（HKDC 1）是近年来发现的一种具有己糖激酶活性的蛋白质，与妊娠期糖代谢有关。在这里，我们讨论了最近的证据表明，新的HKDC 1在妊娠期葡萄糖稳态和GDM和显性糖尿病的发展中的作用。全基因组关联研究确定了与母体葡萄糖代谢相关的HKDC 1基因变体。调节妊娠小鼠HKDC 1蛋白表达的研究表明，HKDC 1在全身葡萄糖利用和营养平衡中发挥作用，肝脏特异性HKDC 1影响胰岛素敏感性、葡萄糖耐量、糖异生和酮产生。HKDC 1在维持母体葡萄糖稳态方面具有重要作用，其功能超出了传统的己糖激酶功能，并可能作为潜在的治疗靶点。
Gestational diabetes mellitus (GDM) is a common pregnancy complication conferring an increased risk to the individual of developing type 2 diabetes. As such, a thorough understanding of the pathophysiology of GDM is warranted. Hexokinase domain containing protein-1 (HKDC1) is a recently discovered protein containing hexokinase activity which has been shown to be associated with glucose metabolism during pregnancy. Here, we discuss recent evidence suggesting roles for the novel HKDC1 in gestational glucose homeostasis and the development of GDM and overt diabetes. Genome wide association studies identified variants of the HKDC1 gene associated with maternal glucose metabolism. Studies modulating HKDC1 protein expression in pregnant mice demonstrate that HKDC1 has roles in whole-body glucose utilization and nutrient balance, with liver-specific HKDC1 influencing insulin sensitivity, glucose tolerance, gluconeogenesis, and ketone production. HKDC1 has important roles in maintaining maternal glucose homeostasis extending beyond traditional hexokinase functions, and may serve as a potential therapeutic target.
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影响因子：
16.6
作者：
Guo C;Ludvik AE;Arlotto ME;Hayes MG;Armstrong LL;Scholtens DM;Brown CD;Newgard CB;Becker TC;Layden BT;Lowe WL;Reddy TE
通讯作者：
Reddy TE
影响因子：
16.2
作者：
American Diabetes Association
通讯作者：
American Diabetes Association
影响因子：
11.1
作者：
Fuhr L;El-Athman R;Scrima R;Cela O;Carbone A;Knoop H;Li Y;Hoffmann K;Laukkanen MO;Corcione F;Steuer R;Meyer TF;Mazzoccoli G;Capitanio N;Relógio A
通讯作者：
Relógio A
影响因子：
2.1
作者：
Bong IPN;Ng CC;Baharuddin P;Zakaria Z
通讯作者：
Zakaria Z
影响因子：
21.3
作者：
通讯作者：
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