Nuclear receptor small heterodimer partner in apoptosis signaling and liver cancer.
Nuclear receptor small heterodimer partner in apoptosis signaling and liver cancer.
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DOI：
10.3390/cancers3010198
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发表时间：
2011-01-05
期刊：
影响因子：
5.2
通讯作者：
Wang L
中科院分区：
文献类型：
--
作者：
Zhang Y;Wang L
小二聚体(SHP，NR0B2)是一种独特的孤儿核受体，它含有二聚体和一个可能的配体结合域，但缺乏保守的DNA结合域。SHP通过与多种核受体和转录因子的物理相互作用，发挥其作为基因转录抑制因子的生理功能。SHP是一种关键的转录调节因子，影响多种生物学功能，包括胆汁酸、胆固醇和脂肪代谢、葡萄糖和能量平衡以及生殖生物学。最近，我们和其他人证明了SHP是一种受表观遗传调控的转录抑制因子，可以抑制肝癌的发展。本文综述了SHP在细胞增殖、细胞凋亡和DNA甲基化中的作用，并讨论了SHP作为肿瘤抑制因子在肝癌发生发展中作用的最新研究进展。未来的研究将集中在寻找SHP相关的新的原癌基因和抑癌基因在肝癌进展中，并将SHP方面的知识应用于肝癌的预防、诊断和治疗。
Small heterodimer partner (SHP, NR0B2) is a unique orphan nuclear receptor that contains the dimerization and a putative ligand-binding domain, but lacks the conserved DNA binding domain. SHP exerts its physiological function as an inhibitor of gene transcription through physical interaction with multiple nuclear receptors and transcriptional factors. SHP is a critical transcriptional regulator affecting diverse biological functions, including bile acid, cholesterol and lipid metabolism, glucose and energy homeostasis, and reproductive biology. Recently, we and others have demonstrated that SHP is an epigenetically regulated transcriptional repressor that suppresses the development of liver cancer. In this review, we summarize recent major findings regarding the role of SHP in cell proliferation, apoptosis, and DNA methylation, and discuss recent progress in understanding the function of SHP as a tumor suppressor in the development of liver cancer. Future study will be focused on identifying SHP associated novel prooncogenes and anti-oncogenes in liver cancer progression and applying the knowledge gained on SHP in liver cancer prevention, diagnosis and treatment.