Increased dopamine level enhances male-male courtship in Drosophila
Increased dopamine level enhances male-male courtship in Drosophila
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多巴胺水平的增加增强了果蝇的雄性求爱。
DOI：
10.1523/jneurosci.5290-07.2008
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发表时间：
2008-05-21
影响因子：
5.3
通讯作者：
Guo, Aike
中科院分区：
文献类型：
--
作者：
Liu, Tong;Dartevelle, Laurence;Guo, Aike
在许多物种中都可以观察到雄性之间的性行为，但其中的生物学因素却鲜为人知。在哺乳动物中，多巴胺的操纵揭示了这种神经调节剂在雄性性行为中的作用。我们使用遗传和药理学方法来操纵果蝇多巴胺能细胞中的多巴胺水平，并研究了这种操纵对雄性雄性求爱行为的影响。多巴胺水平增加的雄性表现出追求其他雄性的倾向，但对处女雌性的求爱，一般嗅觉反应，一般味觉反应或运动活动没有改变。我们的研究结果表明，这些被操纵的雄性表现出的高强度的雄性互动与它们对其他雄性的感官知觉改变有关。
Sexual behavior between males is observed in many species, but the biological factors involved are poorly known. In mammals, manipulation of dopamine has revealed the role of this neuromodulator on male sexual behavior. We used genetic and pharmacological approaches to manipulate the dopamine level in dopaminergic cells in Drosophila and investigated the consequence of this manipulation on male-male courtship behavior. Males with increased dopamine level showed enhanced propensity to court other males but did not change their courtship toward virgin females, general olfactory response, general gustatory response, or locomotor activity. Our results indicate that the high intensity of male-male interaction shown by these manipulated males was related to their altered sensory perception of other males.