Potential Use of Gluconate in Cancer Therapy
Potential Use of Gluconate in Cancer Therapy
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DOI：
10.3389/fonc.2019.00522
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发表时间：
2019-06-19
影响因子：
4.7
通讯作者：
Geissler, Edward K.
中科院分区：
文献类型：
--
作者：
Mycielska, Maria E.;Mohr, Markus T. J.;Geissler, Edward K.
我们最近发现，癌细胞通过质膜柠檬酸盐转运蛋白（pmCiC）摄取细胞外柠檬酸盐，并有利地将柠檬酸盐用于其代谢。柠檬酸盐摄取可以被葡萄糖酸盐阻断，这导致肿瘤生长减少和肿瘤组织代谢特征改变。有趣的是，葡萄糖酸盐，被认为是生理中性的，在医学中偶尔被用作阳离子载体，而不是作为治疗活性物质。在这篇综述中，我们讨论了我们最近的研究结果与现有的文献，并建议葡萄糖酸盐可能是有用的治疗癌症。
We have recently discovered that cancer cells take up extracellular citrate through plasma membrane citrate transporter (pmCiC) and advantageously use citrate for their metabolism. Citrate uptake can be blocked with gluconate and this results in decreased tumor growth and altered metabolic characteristics of tumor tissue. Interestingly, gluconate, considered to be physiologically neutral, is incidentally used in medicine as a cation carrier, but not as a therapeutically active substance. In this review we discuss the results of our recent research with available literature and suggest that gluconate may be useful in the treatment of cancer.