Activation of glial cells by human coronavirus OC43 infection
Activation of glial cells by human coronavirus OC43 infection
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DOI：
10.1016/s0165-5728(00)00266-6
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发表时间：
2000-08-01
影响因子：
3.3
通讯作者：
Talbot, PJ
中科院分区：
文献类型：
--
作者：
Edwards, JA;Denis, F;Talbot, PJ
多发性硬化症（MS）是一种免疫介导的脱髓鞘疾病，可能由病毒感染引发。冠状病毒在啮齿类动物中诱导MS样疾病，是人类的神经侵袭性疾病，并且可以感染人类星形胶质细胞和小胶质细胞的原代培养物。人冠状病毒OC 43株感染人星形胶质细胞系U-373 MG，导致IL-6、TNF-α和MCP-1 mRNA表达上调。该病毒还调节基质金属蛋白酶-2和-9的活性，并增加U-373 MG细胞和人小胶质细胞系CHME-5中一氧化氮的产生。因此，神经胶质细胞的冠状病毒感染可能导致产生与中枢神经系统病理学相关的炎症分子，如MS。（C）2000 Elsevier Science B. V.保留所有权利。
Multiple sclerosis (MS) is an immune-mediated demyelinating disease that could be triggered by a viral infection. Coronaviruses induce an MS-like disease in rodents, are neuroinvasive iri humans and can infect primary cultures of human astrocytes and microglia. Infection of the human astrocytic cell line U-373MG by the OC43 strain of human coronavirus caused an upregulation of IL-6, TNF-alpha, and MCP-1 mRNA expression. This virus also modulated the activity of matrix metalloproteinases-2 and -9 and augmented nitric oxide production in both U-373MG cells and the human microglial cell line CHME-5. Thus, a coronaviral infection of glial cells could lead to the production of inflammatory molecules that have been associated with central nervous system pathologies such as MS. (C) 2000 Elsevier Science B.V. All rights reserved.