Structural, Spectroscopic and Thermal Analysis of Cocrystals of Carbamazepine and Piracetam with Hydroquinone
Structural, Spectroscopic and Thermal Analysis of Cocrystals of Carbamazepine and Piracetam with Hydroquinone
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卡马西平和吡拉西坦与对苯二酚共晶的结构、光谱和热分析
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发表时间：
2011
期刊：
影响因子：
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通讯作者：
R. Tan
中科院分区：
文献类型：
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作者：
S. Aitipamula;P. Chow;R. Tan
报道了卡马西平和吡拉西坦两种重要活性药物成分与对苯二酚的共晶。采用固体研磨法研究了所选原料药与对苯二酚之间的共晶形成。两种晶体结构均属于三斜的$$P ar{1}$$空间群，卡马西平和对苯二酚共晶的单位胞参数为a = 6.9725 （14） Å， b = 8.8175 （18） Å， c = 15.083 (3) Å， α = 106.96(3)°，β = 92.16(3)°，γ = 103.23(3)°，V = 858.0 (4) Å3, Z = 2；吡西坦与对苯二酚共晶的胞元参数为a = 6.4909 （13） Å， b = 6.5410 （13） Å， c = 11.612 (2) Å， α = 103.92(3)°，β = 104.53(3)°，γ = 91.06(3)°，V = 461.59 （18） Å3, Z = 2。对共晶的分析表明，它们是由一个醇-羧酰胺杂合子维持的。此外，卡马西平与对苯二酚的共晶具有酰胺-醇杂合子和醇-醇同合子。吡拉西坦和对苯二酚的共晶具有酰胺-酰胺二聚体合成器。共晶的形成可以从振动频率的变化中得到证明，这些频率与共晶组分上存在的官能团相对应。摘要制备了卡马西平和吡拉西坦与对苯二酚共晶，并通过红外光谱、热分析、粉末和单晶x射线衍射对其进行了表征。晶体结构分析表明，这两种共晶都是由醇酰胺杂合子维持的，而吡拉西坦和对苯二酚的共晶则是由酰胺酰胺二聚体维持的。
Cocrystals of two important active pharmaceutical ingredients, carbamazepine and piracetam, with hydroquinone are reported. Cocrystal formation between the selected APIs and hydroquinone is investigated with the aid of solid-state grinding methods. Both the crystal structures belong to the triclinic, $$P ar{1}$$ space group, with the cocrystal involving carbamazepine and hydroquinone having the unit cell parameters a = 6.9725 (14) Å, b = 8.8175 (18) Å, c = 15.083 (3) Å, α = 106.96 (3)°, β = 92.16 (3)°, γ = 103.23 (3)°, V = 858.0 (4) Å3 and Z = 2; and the cocrystal involving piracetam and hydroquinone has the unit cell parameters a = 6.4909 (13) Å, b = 6.5410 (13) Å, c = 11.612 (2) Å, α = 103.92 (3)°, β = 104.53 (3)°, γ = 91.06 (3)°, V = 461.59 (18) Å3 and Z = 2. Analysis of the cocrystals revealed that they are sustained by an alcohol–carboxamide heterosynthon. In addition, the cocrystal of carbamazepine and hydroquinone features an amide–alcohol heterosynthon and an alcohol–alcohol homosynthon. The cocrystal of piracetam and hydroquinone features an amide–amide dimer synthon. Cocrystal formation was evidenced from the shifts in the vibrational frequencies corresponding to the functional groups present on the cocrystal components.Graphical AbstractCocrystals of carbamazepine and piracetam with hydroquinone were prepared, and characterized by FT-IR spectroscopy, thermal analysis, and powder and single-crystal X-ray diffraction. Analysis of the crystal structures revealed that both the cocrystals are sustained by alcohol–amide heterosynthon and the cocrystal involving piracetam and hydroquinone features an amide–amide dimer synthon.