Preservation of stem cells
Preservation of stem cells
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DOI：
10.4161/org.5.3.9585
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发表时间：
2009-07-01
期刊：
影响因子：
2.3
通讯作者：
Hubel, Allison
中科院分区：
文献类型：
--
作者：
Hanna, Jacob;Hubel, Allison
成人干细胞（造血和间充质）已经显示出巨大的治疗潜力。目前，人类胚胎干细胞主要用于了解发育和疾病进展，但也具有巨大的治疗潜力。保存干细胞的能力对于它们在临床和研究中的应用至关重要。细胞的保存允许细胞在站点之间的运输，以及完成安全和质量控制测试。保存还允许细胞疗法的“制造范式”的发展，从而最大限度地提高在给定设施中可以生产的产品数量。本文将对造血干细胞、间充质干细胞和人胚胎干细胞的保存方式和保存现状进行综述。当前和新出现的问题，在干细胞保存领域也将被描述。
Adult stem cells (hematopoietic and mesenchymal) have demonstrated tremendous human therapeutic potential. Currently, human embryonic stem cells are used principally for understanding development and disease progression but also hold tremendous therapeutic potential. The ability to preserve stem cells is critical for their use in clinical and research applications. Preservation of cells permits the transportation of cells between sites, as well as completion of safety and quality control testing. Preservation also permits the development of a 'manufacturing paradigm' for cell therapies, thereby maximizing the number of products that can be produced at a given facility. In this article, we will review modes of preservation and the current status of preservation of hematopoietic, mesenchymal and human embryonic stem cells. Current and emerging issues in the area of stem cell preservation will also be described.