Hepatitis B infection in pediatric dialysis and transplant patients: significance of e antigen.
Hepatitis B infection in pediatric dialysis and transplant patients: significance of e antigen.
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儿科透析和移植患者的乙型肝炎感染：e 抗原的意义。
DOI：
10.1016/s0022-3476(80)80007-2
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
Fine,RN
中科院分区：
文献类型：
--
作者：
Ettenger,RB;Tong,MJ;Landing,BH;Mosley,J;Malekzadeh,MH;Pennisi,AJ;Uittenbogaart,CH;Jordan,SC;Wright,H;Fine,RN
我们检查了 36 名 HBsAg 阳性儿科透析和肾移植患者中 Be 型肝炎抗原血症的临床意义。对 127 份血清进行了 HBeAg 和抗 HBe 检测。 29 名患者 (81%) 的 73 份血清 (57%) 含有 HBeAg。 HBeAg 的存在与 HBsAg 滴度增加 (P<0.005) 以及 HBsAg 携带状态的存在相关 (P<0.001)。 40% 的透析患者标本和 70% 的移植患者标本检出 HBeAg（P<0.001）。尽管测试的 29 份血清中有 28 份 (9%) 含有 HBcAg 抗体，但没有血清含有抗 HBe。未发现 HBeAg 的存在与血清氨基亮氨酸转移酶水平或慢性活动性肝炎的组织学证据之间存在关联。对来自 HBsAg 持续阳性患者的 15 份 HBeAg 阴性血清进行了 HBV 特异性 DNA 聚合酶活性检测； 7（47%）有显着的活动。由于 HBeAg 和 DNA p 都是传染性的指标，因此来自免疫抑制的 HBsAg 携带者的许多 HBeAg 阴性血清可能具有传染性。
We examined the clinical significance of hepatitis Be antigenemia in 36 HBsAg positive pediatric dialysis and renal transplant patients. One hundred twenty-seven sera were tested for HBeAg and anti-HBe. Seventy-three sera (57%) from 29 patients (81%) contained HBeAg. The presence of HBeAg was associated with an increased titer of HBsAg (P<0.005) and with the presence of the HBsAg carrier state (P<0.001). HBeAg was found in 40% of specimens taken from dialysis patients, and in 70% of specimens from transplant patients (P<0.001). No serum contained anti-HBe, although 28 of 29 sera (9%) tested had antibody to HBcAg. No association was found between the presence of HBeAg and serum aminoleucine transferase levels or the histologic evidence of chronic active hepatitis. Fifteen HBeAg negative sera from patients persistently positive for HBsAg were tested for HBV-specific DNA polymerase activity; 7 (47%) had significant activity. Since both HBeAg and DNA p are indicators of infectivity, many HBeAg negative sera from immunosuppressed HBsAg carriers may be infectious.