Bromotheoynic acid, a brominated acetylenic acid from the marine sponge Theonella swinhoei
Bromotheoynic acid, a brominated acetylenic acid from the marine sponge Theonella swinhoei
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Bromotheoynic Acid，一种来自海洋海绵 Theonella swinhoei 的溴化乙炔酸
DOI：
10.1080/14786419.2012.660636
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发表时间：
2012
影响因子：
2.2
通讯作者：
S.Ohta
中科院分区：
文献类型：
--
作者：
N.Aoki;K.Yamamoto;T. Ogawa;E.Ohta;T.Ikeuchi;K.Kamemura;S.Ikegami;S.Ohta
从日本鹿儿岛县种子岛海域采集的海绵中分离出一种新的溴化c17乙酰酸(1)，命名为溴聚糖酸。该结构是在分析其广泛的二维核磁共振光谱数据和HRMS的基础上确定的。溴甲酸(1)抑制海星卵母细胞的成熟和受精卵的细胞分裂。溴原糖酸(1)还能抑制人白血病U937和HL60细胞、人肺癌A549和H1299细胞以及人胚胎肾293 （HEK293）细胞的增殖。
A new brominated C17acetylenic acid (1) designated as bromotheoynic acid has been isolated from the marine spongeTheonella swinhoei, collected off the coast of Tanegashima, Kagoshima Prefecture, Japan. The structure was determined on the basis of the analysis of its extensive 2D NMR spectroscopic data as well as HRMS. Bromotheoynic acid (1) inhibited maturation of starfish oocytes and cell division of fertilised starfish eggs. Bromotheoynic acid (1) also inhibited proliferation of human leukaemia U937 and HL60 cells, human lung cancer A549 and H1299 cells, and human embryonic kidney 293 (HEK293) cells.