Dietary fiber intake and reduced risk of coronary heart disease in US men and women - The National Health and Nutrition Examination Survey I Epidemiologic Follow-up Study
Dietary fiber intake and reduced risk of coronary heart disease in US men and women - The National Health and Nutrition Examination Survey I Epidemiologic Follow-up Study
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DOI：
10.1001/archinte.163.16.1897
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发表时间：
2003-09-08
影响因子：
--
通讯作者：
Whelton, PK
中科院分区：
文献类型：
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作者：
Bazzano, LA;He, J;Whelton, PK
背景资料：前瞻性研究表明，膳食纤维的摄入量，尤其是水溶性纤维，可能与冠心病（CHD）的风险呈负相关。我们在9776名参加国家健康与营养调查I流行病学随访的成年人中研究了总膳食纤维和可溶性膳食纤维摄入量与冠心病和心血管疾病（CVD）风险之间的关系。在基线时无CVD。在基线检查时进行24小时饮食回忆，并使用Food Processor软件计算营养素摄入量。冠心病和心血管疾病的发病率和死亡率的数据，从医疗记录和死亡证明书在follow-up.Results：在平均19年的后续行动，1843例冠心病和3762例心血管疾病的事件记录。与膳食纤维摄入量的最低四分位数相比（中位数，5.9 g/d），最高四分位数的参与者（中位数，20.7 g/d）的校正相对风险为0.88（95%置信区间[CI]，0.74-1.04;趋势P=.05），CVD事件为0.89（95% CI，0.80-0.99;趋势P=.01）。水溶性膳食纤维摄入量最高（中位数，5.9 g/d）与最低（中位数，0.9 g/d）四分位数的人相比，CHD事件的相对风险为0.85（95%CI，0.74-0.98; P= 0.004趋势），CVD事件的相对风险为0.90（95%CI，0.82-0.99; P= 0.01趋势）。
Background: Prospective studies suggest that dietary fiber intake, especially water-soluble fiber, may be inversely associated with the risk of coronary heart disease (CHD).Methods: We examined the relationship between total and soluble dietary fiber intake and the risk of CHD and cardiovascular disease (CVD) in 9776 adults who participated in the National Health and Nutrition Examination Survey I Epidemiologic Follow-up Study and were free of CVD at baseline. A 24-hour dietary recall was conducted at the baseline examination, and nutrient intakes were calculated using Food Processor software. Incidence and mortality data for CHD and CVD were obtained from medical records and death certificates during follow-up.Results: During an average of 19 years of follow-up, 1843 incident cases of CHD and 3762 incident cases of CVD were documented. Compared with the lowest quartile of dietary fiber intake (median, 5.9 g/d), participants in the highest quartile (median, 20.7 g/d) had an adjusted relative risk of 0.88 (95% confidence interval [CI], 0.74-1.04; P=.05 for trend) for CHD events and of 0.89 (95% CI, 0.80-0.99; P=.01 for trend) for CVD events. The relative risks for those in the highest (median, 5.9 g/d) compared with those in the lowest (median, 0.9 g/d) quartile of water-soluble dietary fiber intake were 0.85 (95% CI, 0.74-0.98; P=.004 for trend) for CHD events and 0.90 (95% CI, 0.82-0.99; P=.01 for trend) for CVD events.