CORTICAL CHOLINERGIC FIBERS IN AGING AND ALZHEIMERS-DISEASE - A MORPHOMETRIC STUDY
CORTICAL CHOLINERGIC FIBERS IN AGING AND ALZHEIMERS-DISEASE - A MORPHOMETRIC STUDY
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DOI：
10.1016/0306-4522(89)90399-0
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发表时间：
1989-01-01
期刊：
影响因子：
3.3
通讯作者：
MESULAM, MM
中科院分区：
文献类型：
--
作者：
GEULA, C;MESULAM, MM
乙酰胆碱酯酶的组织化学方法被用来评估区域密度的乙酰胆碱酯酶丰富（嘌呤胆碱能）轴突在大脑皮层。在所有皮质区均观察到这些纤维的密集丛。内嗅区、扣带回和颞下区用于定量分析。边缘皮质区（内嗅和扣带回）含有较高密度的乙酰胆碱酯酶丰富的纤维比颞下区TE的联合皮质。在所有三个区域中，较浅的层比深层含有更密集的纤维网。衰老伴随着适度的损失，乙酰胆碱酯酶阳性纤维的密度内嗅和下颞叶皮质，但不是在扣带区。在阿尔茨海默病患者的大脑中，在所有三个检查区域都观察到这些纤维的急剧损失，但在扣带区的损失相对不那么明显。结果表明，人脑大脑皮层的胆碱能神经支配具有明显的区域性和层次性差异。在正常衰老和阿尔茨海默病的结果中，也观察到皮质胆碱能纤维的变化存在区域差异。与老年痴呆症患者相比，老年人大脑皮层胆碱能纤维密度随年龄增长而降低的程度是相当温和的。
A histochemical method for acetylcholinesterase was used to assess the regional density of acetylcholinesterase-rich (putatively cholinergic) axons in the cerebral cortex. A dense plexus of these fibers was observed in all cortical areas. The entorhinal, cingulate and inferotemporal regions were used for quantitative analysis. The paralimbic cortical areas (entorhinal and cingulate) contained a higher density of acetylcholinesterase-rich fibers than the association cortex of inferotemporal area TE. The more superficial layers in all three regions contained denser net of thee fibers than did the deep layers. Aging was accompanied by a modest loss in the density of acetylcholinesterase-positive fibers in the entorhinal and inferotemporal cortex but not in the cingulate area. In brains from patients with Alzheimer''s disease, a dramatic loss of these fibers was observed in all three areas examined but the loss was relatively less pronounced in the cingulate area. The results demonstrate that the cholinergic innervation of the cerebral cortex in the human brain displays considerable regional and laminar variations. Regional variations were also observed in the alterations that the cortical cholinergic fibers displayed as a result of normal aging and Alzheimer''s disease. The age-related reduction observed in the density of cholinergic fibers in the cerebral cortex was quite modest when compared with the dramatic loss in Alzheimer''s disease.