Neuropsychological correlates of symptom dimensions in inpatients with major depressive disorder
Neuropsychological correlates of symptom dimensions in inpatients with major depressive disorder
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DOI：
10.1016/j.psychres.2013.01.018
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发表时间：
2013-05-15
影响因子：
11.3
通讯作者：
Bornstein, Robert
中科院分区：
文献类型：
--
作者：
Basso, Michael;Combs, Dennis;Bornstein, Robert
重度抑郁症（MDD）的症状在个体中表现出差异。因此，最近的模型的障碍意味着，MDD的特点是根据独立的症状维度。特别是，几项研究表明，抑郁症的特点可能是沿着维度的负面影响，激动和敌意，以及倦怠和不适。没有研究探讨这些维度和神经心理功能之间的关系。为此，133名单极MDD患者和17名无精神疾病的患者接受了简短的神经心理学测试和MMPI-2。MMPI-2的主成分分析揭示了消极情感、激动、倦怠和不适的症状维度。多元回归分析表明，负性情感和激动维度解释了执行功能，信息处理速度，新的学习，灵活性和整体障碍的措施显着的方差。疲劳和不适未能对应的神经心理学性能。这些数据的临床实践和神经模型的MDD的影响进行了讨论。(c)2013爱思唯尔爱尔兰有限公司版权所有。
Symptoms of major depressive disorder (MDD) manifest variably across individuals. Accordingly, recent models of the disorder imply that MDD may be characterized according to independent symptom dimensions. In particular, several studies reveal that depression may be characterized along dimensions of negative affect, agitation and hostility, and lassitude and malaise. No research has examined the relationship between these dimensions and neuropsychological function. Towards this end, 133 in patients with unipolar MDD and 17 people without psychiatric illness were administered a brief battery of neuropsychological tests and the MMPI-2. Paralleling earlier research, principal component analysis of the MMPI-2 revealed symptom dimensions of negative affect, agitation, and lassitude and malaise. Multiple regression analyses showed that the negative affect and agitation dimensions accounted for significant variance on measures of executive function, speed of information processing, new learning, dexterity, and overall impairment. Lassitude and malaise failed to correspond with neuropsychological performance. Implications of these data for clinical practice and neural models of MDD are discussed. (c) 2013 Elsevier Ireland Ltd. All rights reserved.