The t(4;14) translocation and FGFR3 overexpression in multiple myeloma: prognostic implications and current clinical strategies.
The t(4;14) translocation and FGFR3 overexpression in multiple myeloma: prognostic implications and current clinical strategies.
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DOI：
10.1038/bcj.2012.37
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发表时间：
2012-09-07
影响因子：
12.8
通讯作者：
Spencer, A.
中科院分区：
文献类型：
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作者：
Kalff, A.;Spencer, A.
多发性骨髓瘤（MM）是一种以遗传异常为特征的异质性浆细胞疾病，包括染色体易位、缺失、重复和基因突变。在大约40%的MM患者中观察到涉及染色体14q32的免疫球蛋白重链区域的易位。癌基因易位到该区域可能导致其表达增加，从而导致疾病的发生、疾病的进展和治疗耐药性。t（4;14）易位与成纤维细胞生长因子受体3 （FGFR3）和骨髓瘤SET结构域蛋白的上调有关。t（4;14）患者总体预后较差，仅通过使用新型药物硼替佐米和来那度胺部分缓解；因此，这种异常患者的医疗需求仍未得到满足。FGFR3抑制剂的临床前研究在t(4;14) MM中显示出前景，这些研究已导致临床试验的启动。这些试验的数据将有助于确定FGFR3抑制剂对t(4;14) MM患者的临床效用，并可能为这种不治之症患者的个性化治疗铺平道路。
Multiple myeloma (MM) is a heterogeneous plasma cell disorder characterized by genetic abnormalities, including chromosomal translocations, deletions, duplications and genetic mutations. Translocations involving the immunoglobulin heavy chain region at chromosome 14q32 are observed in approximately 40% of patients with MM. Translocation of oncogenes into this region may lead to their increased expression, contributing to disease initiation, disease progression and therapeutic resistance. The t(4;14) translocation is associated with upregulation of the fibroblast growth factor receptor 3 (FGFR3) and the myeloma SET domain protein. Patients with t(4;14) demonstrate an overall poor prognosis that is only partially mitigated by the use of the novel agents bortezomib and lenalidomide; as such, an unmet medical need remains for patients with this aberration. Preclinical studies of inhibitors of FGFR3 have shown promise in t(4;14) MM, and these studies have led to the initiation of clinical trials. Data from these trials will help to determine the clinical utility of FGFR3 inhibitors for patients with t(4;14) MM and may pave the way for personalized medicine in patients with this incurable disease.
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影响因子：
45.3
作者：
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通讯作者：
Minvielle, Stephane
影响因子：
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影响因子：
11.5
作者：
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通讯作者：
Kienast, Joachim
影响因子：
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