Altered sarco(endo)plasmic reticulum calcium adenosine triphosphatase 2a content: Targets for heart failure therapy
Altered sarco(endo)plasmic reticulum calcium adenosine triphosphatase 2a content: Targets for heart failure therapy
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改变肌（内）质网钙腺苷三磷酸酶 2a 含量：心力衰竭治疗的目标
DOI：
10.1177/1479164118774313
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发表时间：
2018-05
影响因子：
2.4
通讯作者：
Tong Xiao Yong
中科院分区：
文献类型：
--
作者：
Liu Gang;Li Si Qi;Hu Ping Ping;Tong Xiao Yong
Sarco（内）质网钙腺苷三磷酸酶负责将胞质钙转运到肌浆网和内质网，以维持钙的稳态。Sarco（endo）质网钙腺苷三磷酸酶是在心脏组织中表达的主要亚型，受内源性蛋白抑制剂、翻译后修饰、激素以及microrna的调节。sarco（endo）质网钙腺苷三磷酸酶功能障碍与心力衰竭有关，这使得sarco（endo）质网钙腺苷三磷酸酶成为心力衰竭治疗的一个有希望的靶点。本文综述了目前改善sarco（endo）质网钙腺苷三磷酸酶功能的方法，重点介绍了内源性sarco（endo）质网钙腺苷三磷酸酶抑制剂磷蛋白、药物工具和基因治疗。
Sarco(endo)plasmic reticulum calcium adenosine triphosphatase is responsible for transporting cytosolic calcium into the sarcoplasmic reticulum and endoplasmic reticulum to maintain calcium homeostasis. Sarco(endo)plasmic reticulum calcium adenosine triphosphatase is the dominant isoform expressed in cardiac tissue, which is regulated by endogenous protein inhibitors, post-translational modifications, hormones as well as microRNAs. Dysfunction of sarco(endo)plasmic reticulum calcium adenosine triphosphatase is associated with heart failure, which makes sarco(endo)plasmic reticulum calcium adenosine triphosphatase a promising target for heart failure therapy. This review summarizes current approaches to ameliorate sarco(endo)plasmic reticulum calcium adenosine triphosphatase function and focuses on phospholamban, an endogenous inhibitor of sarco(endo)plasmic reticulum calcium adenosine triphosphatase, pharmacological tools and gene therapies.
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影响因子：
5
作者：
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通讯作者：
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影响因子：
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64.8
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DOI：
10.1152/ajpcell.00352.2003
发表时间：
2004-04
期刊：
American journal of physiology. Cell physiology
影响因子：
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