Clear Cell Cribriform Hyperplasia of Prostate: Report of 10 Cases
Clear Cell Cribriform Hyperplasia of Prostate: Report of 10 Cases
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DOI：
10.1097/00000478-198610000-00001
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发表时间：
1986-10
期刊：
影响因子：
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通讯作者：
A. Ayala;J. Srigley;J. Ro;F. Abdul-Karim;Douglas E. Johnson
中科院分区：
文献类型：
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作者：
A. Ayala;J. Srigley;J. Ro;F. Abdul-Karim;Douglas E. Johnson
我们报告10例前列腺透明细胞筛状增生症。年龄62 ~ 87岁，平均72岁。所有患者的临床诊断均为良性结节性增生;所有患者均存活，且未显示疾病复发的证据。随访时间为1个月至7年（中位数：12.5个月;平均：24.6个月）。病理学上，这种病变有筛状排列的透明细胞，伴有复杂的乳头状生长，类似于前列腺癌的筛状模式。事实上，在10例病例中，有5例的参考诊断是癌或可能的癌。然而，细胞学上，没有核小体、有丝分裂或突出的核仁，典型的是在受累腺泡的周围有双层上皮细胞层。总之，透明细胞筛状增生是一种良性增生过程，具有复杂的乳头状筛状结构，不应与前列腺癌混淆。诊断的关键特征是保留结节状结构，细胞学检查阴性，受累腺泡内有双层细胞层。
We report 10 patients with clear cell cribriform hyperplasia of the prostate. Their ages ranged from 62 to 87 years, with a mean of 72 years. The clinical diagnosis in all patients was benign nodular hyperplasia; all the patients are alive and have shown no evidence of recurrent disease. Follow-ups ranged from 1 month to 7 years (median: 12.5 months; mean: 24.6 months). Pathologically, this lesion has a cribriform arrangement of clear cells with a complex papillary growth simulating the cribriform pattern of prostatic carcinoma. In fact, in five of the 10 cases, the referring diagnosis was either carcinoma or possible carcinoma. Cytologically, however, there is no nuclear atypia, mitosis, or prominent nucleoli, and typically there is a double epithelial cell layer at the periphery of the involved acini. In summary, clear cell cribriform hyperplasia is a benign hyperplastic process with a complex papillary-cribriform structure and should not be confused with prostatic carcinoma. The key feature for the diagnosis is the preservation of nodular configuration with a bland cytology and double cell layer lining the involved acini.