Normal values and determinants of circadian urine production in older men: A population based study
Normal values and determinants of circadian urine production in older men: A population based study
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DOI：
10.1016/s0022-5347(05)64472-2
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发表时间：
2002-10-01
影响因子：
6.6
通讯作者：
Bohnen, AM
中科院分区：
文献类型：
--
作者：
Blanker, MH;Bernsen, RMD;Bohnen, AM
目的：我们在一个基于大量老年男性人群的样本中评估了昼夜尿液产生及其决定因素。
材料与方法：我们收集了1688名50至78岁男性的数据，这些男性未接受过根治性前列腺切除术，没有前列腺癌或膀胱癌、神经源性膀胱疾病，且未得到其全科医生的负面建议，他们是从荷兰克林彭的人群中招募的。测量包括自行填写的问卷（包括国际前列腺症状评分）、一份3天的排尿频率 - 尿量图表、经直肠前列腺超声检查、尿流率测定以及排尿后残余尿量测定。确定每小时的尿液产生量，并根据排尿频率 - 尿量图表计算昼夜尿液产生量之比。
结果：65岁以下的男性呈现出明显的昼夜尿液产生模式，而在老年男性中这种模式不太明显。吸烟、使用利尿剂、排尿后残余尿量以及24小时多尿强化了昼夜模式，更倾向于白天产生尿液。昼夜尿液产生量之比与前列腺增大、尿流率降低、体重、高血压、心脏症状、糖尿病、使用抗抑郁药、心脏或催眠药物无关。
结论：与65岁以上男性相比，65岁以下男性的尿液产生呈现出明显的昼夜模式。这些数据在描述特定人群的尿液产生模式时可作为参考。在日常实践中，排尿频率 - 尿量图表可用于确定尿液产生情况。这种方法成本低廉、易于使用，并能提供自然环境下尿液产生的有效信息。
Purpose: We evaluated circadian urine production and its determinants in a large population based sample of older men.Materials and Methods: We collected data on 1,688 men 50 to 78 years old, without radical prostatectomy, prostate or bladder cancer, neurogenic bladder disease or negative advice from their general practitioner, recruited from the population of Krimpen, the Netherlands. Measurements consisted of self-administered questionnaires, including the International Prostate Symptom Score, a 3-day frequency-volume chart, transrectal prostatic ultrasound, uroflowmetry and post-void residual volume. Hourly urine production was determined and urine production day-to-night ratio was calculated from the frequency-volume chart.Results: Men younger than 65 years showed a clear circadian urine production pattern, whereas in older men this pattern was less clear. Smoking, use of diuretic drugs, post-void residual and 24-hour polyuria reinforced the circadian pattern, in favor of daytime urine production. The urine production day-to-night ratio was not associated with prostate enlargement, reduced urinary flow rate, body weight, hypertension, cardiac symptoms, diabetes mellitus, use of antidepressants, cardiac or hypnotic drugs.Conclusions: Urine production in men younger than 65 years showed a clear circadian pattern in contrast to men older than 65 years. These data can be used as a reference when describing urine production patterns in select populations. In daily practice frequency-volume charts can be used to determine urine production. This method is inexpensive, easy to use and provides valid information on urine production in a natural environment.