Early transmissibility assessment of the N501Y mutant strains of SARS-CoV-2 in the United Kingdom, October to November 2020.
Early transmissibility assessment of the N501Y mutant strains of SARS-CoV-2 in the United Kingdom, October to November 2020.
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DOI：
10.2807/1560-7917.es.2020.26.1.2002106
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发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Wu JT
中科院分区：
文献类型：
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作者：
Leung K;Shum MH;Leung GM;Lam TT;Wu JT
在刺突蛋白的受体结合域中具有N501 Y突变的两种新的SARS-CoV-2谱系在英国迅速传播。我们估计，主要在9月初至11月中旬之间传播的没有氨基酸缺失Δ69/Δ70的早期501 Y谱系的传播性比501 N谱系高10%（6-13%），而从9月下旬开始传播的具有氨基酸缺失Δ69/Δ70的501 Y谱系的传播性比501 N谱系高75%（70-80%）。
Two new SARS-CoV-2 lineages with the N501Y mutation in the receptor-binding domain of the spike protein spread rapidly in the United Kingdom. We estimated that the earlier 501Y lineage without amino acid deletion Δ69/Δ70, circulating mainly between early September and mid-November, was 10% (6–13%) more transmissible than the 501N lineage, and the 501Y lineage with amino acid deletion Δ69/Δ70, circulating since late September, was 75% (70–80%) more transmissible than the 501N lineage.