Ferroptosis at the intersection of lipid metabolism and cellular signaling.
Ferroptosis at the intersection of lipid metabolism and cellular signaling.
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DOI：
10.1016/j.molcel.2022.03.022
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发表时间：
2022-06-16
期刊：
影响因子：
16
通讯作者：
Jiang, Xuejun
中科院分区：
文献类型：
--
作者：
Liang, Deguang;Minikes, Alexander M.;Jiang, Xuejun
铁死亡是一种新出现的调节性坏死细胞死亡形式，已被证明在多种疾病中发挥重要作用，包括癌症、神经变性和缺血性器官损伤。越来越多的证据还表明其在肿瘤抑制和免疫方面的潜在生理功能。铁死亡的执行是由铁依赖性磷脂过氧化作用驱动的。因此，生物脂质的代谢通过控制磷脂过氧化以及与磷脂过氧化相关的各种其他细胞过程来调节铁死亡。在这篇综述中，我们将重点关注脂质代谢如何影响磷脂过氧化的起始、传播和终止，多种信号转导途径如何通过调节脂质代谢与铁死亡进行通讯，以及如何利用铁死亡与脂质代谢和相关信号通路的这种密切串扰来制定合理的治疗策略。在这篇评论中，梁等人。描述脂质代谢在铁死亡中的关键作用以及调节脂质代谢的各种信号通路的最新进展；他们还强调了该领域一些尚未解答的问题，并提出了潜在的基于铁死亡诱导的癌症治疗策略。
Ferroptosis, a newly emerged form of regulated necrotic cell death, has been demonstrated to play an important role in multiple diseases including cancer, neurodegeneration, and ischemic organ injury. Mounting evidence also suggests its potential physiological function in tumor suppression and immunity. Execution of ferroptosis is driven by iron-dependent phospholipid peroxidation. As such, metabolism of biological lipids regulates ferroptosis via controlling phospholipid peroxidation, as well as various other cellular processes relevant to phospholipid peroxidation. In this review, we will provide a comprehensive analysis by focusing on how lipid metabolism impacts the initiation, propagation, and termination of phospholipid peroxidation, how multiple signal transduction pathways communicate with ferroptosis via modulating lipid metabolism, and how such intimate crosstalk of ferroptosis with lipid metabolism and related signaling pathways can be exploited for the development of rational therapeutic strategies. In this review, Liang et al. describe the recent development on the pivotal role of lipid metabolism, as well as various signaling pathways that modulate lipid metabolism, in ferroptosis; they also highlight some unanswered questions in the field and suggest potential ferroptosis induction-based cancer therapeutic strategies.
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ACSL4 通过塑造细胞脂质成分来决定铁死亡敏感性。
影响因子：
14.8
作者：
Doll S;Proneth B;Tyurina YY;Panzilius E;Kobayashi S;Ingold I;Irmler M;Beckers J;Aichler M;Walch A;Prokisch H;Trümbach D;Mao G;Qu F;Bayir H;Füllekrug J;Scheel CH;Wurst W;Schick JA;Kagan VE;Angeli JP;Conrad M
通讯作者：
Conrad M
影响因子：
64.5
作者：
Dixon SJ;Lemberg KM;Lamprecht MR;Skouta R;Zaitsev EM;Gleason CE;Patel DN;Bauer AJ;Cantley AM;Yang WS;Morrison B 3rd;Stockwell BR
通讯作者：
Stockwell BR
影响因子：
4
作者：
Dixon SJ;Winter GE;Musavi LS;Lee ED;Snijder B;Rebsamen M;Superti-Furga G;Stockwell BR
通讯作者：
Stockwell BR
影响因子：
64.8
作者：
Ghandi, Mahmoud;Huang, Franklin W.;Sellers, William R.
通讯作者：
Sellers, William R.
DOI：
10.1073/pnas.2009201117
发表时间：
2020-11-03
影响因子：
11.1
作者：
Beharier, Ofer;Tyurin, Vladimir A.;Sadovsky, Yoel
通讯作者：
Sadovsky, Yoel