Migration capacity of human umbilical cord mesenchymal stem cells towards glioma in vivo.
Migration capacity of human umbilical cord mesenchymal stem cells towards glioma in vivo.
复制标题
人脐带间充质干细胞体内向胶质瘤的迁移能力
DOI：
10.3969/j.issn.1673-5374.2013.22.009
复制
发表时间：
2013-08-05
影响因子：
6.1
通讯作者：
Zhou J
中科院分区：
文献类型：
--
作者：
Fan C;Wang D;Zhang Q;Zhou J
高级别神经胶质瘤是成人最常见的原发性恶性脑肿瘤。胶质瘤预后差，加上对现有治疗方法的耐药性，需要更有效的肿瘤选择性治疗。干细胞疗法是一种新型的基于细胞的药物递送载体。本研究成功地通过外植体培养分离了人脐带间充质干细胞。人脐带间充质干细胞粘附于塑料表面，流式细胞术证实其表达间充质干细胞的特异性表面表型，并在体外诱导介质中具有多向分化的潜能。此外，人脐带间充质干细胞在瘤内注射或对侧心室给药后，在已建立的大鼠胶质瘤模型中表现出优异的胶质瘤特异性靶向能力。人脐带间充质干细胞优异的胶质瘤特异性靶向能力和广泛的瘤内分布表明，它们可能作为一种新的细胞载体，在胶质瘤治疗中递送治疗分子。
High-grade glioma is the most common malignant primary brain tumor in adults. The poor prognosis of glioma, combined with a resistance to currently available treatments, necessitates the ment of more effective tumor-selective therapies. Stem cell-based therapies are emerging as novel cell-based delivery vehicle for therapeutic agents. In the present study, we successfully isolated human umbilical cord mesenchymal stem cells by explant culture. The human umbilical cord senchymal stem cells were adherent to plastic surfaces, expressed specific surface phenotypes of mesenchymal stem cells as demonstrated by flow cytometry, and possessed multi-differentiation potentials in permissive induction media in vitro. Furthermore, human umbilical cord mesenchymal stem cells demonstrated excellent glioma-specific targeting capacity in established rat glioma models after intratumoral injection or contralateral ventricular administration in vivo. The excellent glioma-specific targeting ability and extensive intratumoral distribution of human umbilical cord mesenchymal stem cells indicate that they may serve as a novel cellular vehicle for delivering therapeutic molecules in glioma therapy.
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血小板衍生的生长因子BB介导人间充质干细胞的性质因子神经胶质瘤。
影响因子：
4.8
作者：
Hata N;Shinojima N;Gumin J;Yong R;Marini F;Andreeff M;Lang FF
通讯作者：
Lang FF
影响因子：
3.3
作者：
Boulland, Jean-Luc;Leung, Doreen S. Y.;Glover, Joel C.
通讯作者：
Glover, Joel C.
影响因子：
2.9
作者：
Buie, Larry W.;Valgus, John M.
通讯作者：
Valgus, John M.
DOI：
10.1097/ppo.0b013e3182431c6f
发表时间：
2012-01
期刊：
Cancer journal (Sudbury, Mass.)
影响因子：
--
作者：
Gerstner ER;Batchelor TT
通讯作者：
Batchelor TT
影响因子：
5.8
作者：
Cohen, Martin H.;Shen, Yuan Li;Pazdur, Richard
通讯作者：
Pazdur, Richard