Antimicrobial activity of gallium maltolate against Staphylococcus aureus and methicillin-resistant S. aureus and Staphylococcus pseudintermedius: An in vitro study
Antimicrobial activity of gallium maltolate against Staphylococcus aureus and methicillin-resistant S. aureus and Staphylococcus pseudintermedius: An in vitro study
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DOI：
10.1016/j.vetmic.2011.09.009
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发表时间：
2012-03-23
影响因子：
3.3
通讯作者：
Cohen, Noah D.
中科院分区：
文献类型：
--
作者：
Arnold, Carolyn E.;Bordin, Angela;Cohen, Noah D.
镓是一种三价半金属元素，对几种重要的人类病原体具有抗菌活性。这种抗菌活性可能与它在细菌重要的铁依赖途径中的替代有关。葡萄球菌属，包括引起严重发病率和死亡率的人类和动物病原体，需要铁来生长和定植。在本研究中，50 ~ 200 μ M不同浓度的麦芽糖酸镓在接种后8 ~ 36 h的时间点抑制了金黄色葡萄球菌和耐甲氧西林金黄色葡萄球菌（MRSA）的体外生长。测定了苹果酸镓对某兽医教学医院临床分离的MRSA和耐甲氧西林假中葡萄球菌（MRSP）的抑制活性。(C) 2011 Elsevier B.V.版权所有
Gallium is a trivalent semi-metallic element that has shown antimicrobial activity against several important human pathogens. This antimicrobial activity is likely related to its substitution in important iron-dependent pathways of bacteria. The genus Staphylococcus, which includes human and animal pathogens that cause significant morbidity and mortality, requires iron for growth and colonization. In this study, gallium maltolate, at various concentrations between 50 and 200 mu M, inhibited the in vitro growth of Staphylococcus aureus and methicillin-resistant S. aureus (MRSA) at time-points between 8 and 36 h after inoculation. The inhibitory activity of gallium maltolate against clinical isolates of MRSA and methicillin-resistant Staphylococcus pseudintermedius (MRSP) from a veterinary teaching hospital was determined. (C) 2011 Elsevier B.V. All rights reserved.