Inhibition of matrix metalloproteinases enhances breaking strength of colonic anastomoses in an experimental model
Inhibition of matrix metalloproteinases enhances breaking strength of colonic anastomoses in an experimental model
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DOI：
10.1046/j.1365-2168.2001.01649.x
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发表时间：
2001-02
影响因子：
9.6
通讯作者：
I. Syk;Magnus S. Ågren;D. Adawi;Bengt Jeppsson
中科院分区：
文献类型：
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作者：
I. Syk;Magnus S. Ågren;D. Adawi;Bengt Jeppsson
术后3-4天结肠吻合口断裂强度下降至最低，随后有吻合口破裂的风险。其机制被认为是胶原蛋白被基质金属蛋白酶（MMPs）降解。本研究通过全身给予合成广谱MMP抑制剂BB - 1101，研究了MMPs对结肠吻合口机械强度的致病作用。
The breaking strength of colonic anastomoses declines after operation to a minimum at days 3–4, with a subsequent risk of anastomotic dehiscence. The mechanism is thought to be collagen degradation by matrix metalloproteinases (MMPs). This study examined the pathogenic role of MMPs on the mechanical strength of colonic anastomoses by giving the synthetic broad‐spectrum MMP inhibitor BB‐1101 systemically.