Correction of the bleeding time with lyophilized platelet infusions in dogs on cardiopulmonary bypass
Correction of the bleeding time with lyophilized platelet infusions in dogs on cardiopulmonary bypass
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DOI：
10.1177/1076029607304746
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发表时间：
2008-01-01
影响因子：
2.9
通讯作者：
Fischer, Thomas H.
中科院分区：
文献类型：
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作者：
Bode, Arthur P.;Lust, Robert M.;Fischer, Thomas H.
在心肺旁路灌注2小时后，将冻干犬血小板以单次大推注剂量注入脾切除的狗体内，以测试其在血小板功能受损后恢复止血的可能功效。通过暴露的颈静脉的静脉穿刺来监测血管出血时间（VBT）。在体外循环期间，血小板计数迅速下降，VBT 变得比基线更长。在退出心肺旁路泵之前或之后立即输注在生理盐水中重建的冻干血小板。结果显示，输注的冻干血小板能够一致且持续地降低 VBT。对照组显示 VBT 持续延长。输注受试者的加权平均 VBT 显着低于对照组的平均值：分别为 3 分 10 秒和 6 分 59 秒（t 检验，P = .0 1）。在这种情况下的这些结果表明，类似的人冻干血小板制剂在减少心脏直视手术术后出血方面可能有效
Lyophilized canine platelets were infused in a single large bolus dose into splenectomized dogs after 2 hours' perfusion on cardiopulmonary bypass to test their possible efficacy in restoring hemostasis after compromise of platelet function. The vessel bleeding time (VBT) was monitored by venipuncture of the exposed jugular vein. During cardiopulmonary bypass, platelet counts fell quickly and the VBTs became prolonged over baseline. Infusion of lyophilized platelets reconstituted in normal saline occurred just before or immediately after weaning from the cardiopulmonary bypass pump. The results showed consistent and persistent lowering of the VBTs by the infused lyophilized platelets. Controls showed continuously prolonged VBTs. The weighted average VBT in infused subjects was significantly lower than the average in controls: 3 minutes 10 seconds versus 6 minutes 59 seconds, respectively (t test, P =.0 1). These results in this setting indicate the possible effectiveness of similar human lyophilized platelet preparations in reducing postoperative bleeding in open heart surgery