Peripheral and intraamygdalar administration of the dopamine D1 receptor antagonist SCH 23390 blocks fear-potentiated startle but not shock reactivity or the shock sensitization of acoustic startle
Peripheral and intraamygdalar administration of the dopamine D1 receptor antagonist SCH 23390 blocks fear-potentiated startle but not shock reactivity or the shock sensitization of acoustic startle
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DOI：
10.1037//0735-7044.114.2.262
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发表时间：
2000-04-01
影响因子：
1.9
通讯作者：
Kokkinidis, L
中科院分区：
文献类型：
--
作者：
Greba, Q;Kokkinidis, L
中枢多巴胺(DA)活动被认为在恐惧动机中发挥作用。本研究的目的是评估DA DI受体在情绪学习中的作用。作者报道，外周和杏仁核内给予特异性D-L受体拮抗剂SCH 23390，可阻断恐惧增强惊厥的获得。对足底电击期间电击反应性的分析表明，学习障碍不能用无条件刺激的厌恶特性的减少来解释。此外，全身性注射SCH 23390和杏仁核内注射SCH 23390并没有改变声音惊吓的休克敏感度所测量的恐惧表达。讨论了杏仁间核DA对条件性恐惧反应的习得和提取的潜在贡献。
Central dopamine (DA) activity is thought to play a role in fear motivation. The aim of the present study was to assess the involvement of DA DI receptors in emotional learning. The authors report that peripheral and intraamygdalar administration of the specific D-l receptor antagonist SCH 23390 blocked the acquisition of fear-potentiated startle. Analysis of shock reactivity during footshock administration revealed that the learning impairment could not he explained by a diminution in the aversive properties of the unconditioned stimulus. Additionally, systemic and intraamygdalar injection of SCH 23390 did not alter fear expression as measured with the shock sensitization of acoustic startle. The potential contribution of mesoamygdaloid DA to the acquisition and retrieval of conditioned fear responses is discussed.