Methicillin-Resistant Staphylococcus aureus (MRSA): One Health Perspective Approach to the Bacterium Epidemiology, Virulence Factors, Antibiotic-Resistance, and Zoonotic Impact.
Methicillin-Resistant Staphylococcus aureus (MRSA): One Health Perspective Approach to the Bacterium Epidemiology, Virulence Factors, Antibiotic-Resistance, and Zoonotic Impact.
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DOI：
10.2147/idr.s272733
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发表时间：
2020
影响因子：
3.9
通讯作者：
Mabrok MA
中科院分区：
文献类型：
--
作者：
Algammal AM;Hetta HF;Elkelish A;Alkhalifah DHH;Hozzein WN;Batiha GE;El Nahhas N;Mabrok MA
耐甲氧西林金黄色葡萄球菌（MRSA）是一种主要的人类病原体，也是一种具有重要公共卫生和兽医学意义的人畜共患病原体。在人类中，MRSA通常引起严重的感染性疾病，包括食物中毒、化脓性心内膜炎、化脓性肺炎、中耳炎、骨髓炎和皮肤、软组织的化脓性感染。在马中，MRSA可引起局部化脓性感染和葡萄孢菌病;在牛和母羊中，局部化脓性感染和严重急性乳腺炎伴明显毒血症;在绵羊中，脓肿病类似于由厌氧菌株引起的干酪性淋巴结炎;在狗和猫中，脓疱性皮炎和食物中毒;在猪中，渗出性表皮炎“油腻性猪病;在鸟类中，MRSA引起大蹄病。甲氧西林耐药性可以通过PCR检测mecA基因以及头孢西丁耐药性来确定。在埃及，MRSA是亚临床和临床牛乳腺炎的重要场合之一，MRSA的流行因地理区域而异。在这篇综述中，我们试图说明关于MRSA感染的宿主易感性、疾病、流行病学、毒力因子、抗生素耐药性、治疗和控制的可变数据。
Methicillin-resistant Staphylococcus aureus (MRSA) is a major human pathogen and a historically emergent zoonotic pathogen with public health and veterinary importance. In humans, MRSA commonly causes severe infectious diseases, including food poisoning, pyogenic endocarditis, suppurative pneumonia, otitis media, osteomyelitis, and pyogenic infections of the skin, soft tissues. In the horse, MRSA could cause a localized purulent infection and botryomycosis; in cattle and ewe, localized pyogenic infection and severe acute mastitis with marked toxemia; in sheep, abscess disease resembles caseous lymphadenitis caused by anaerobic strains; in dogs and cats, pustular dermatitis and food poisoning; in pig, exudative epidermatitis “greasy pig disease; in birds, MRSA causes bumble-foot. The methicillin resistance could be determined by PCR-based detection of the mecA gene as well as resistance to cefoxitin. In Egypt, MRSA is one of the important occasions of subclinical and clinical bovine mastitis, and the prevalence of MRSA varies by geographical region. In this review, we are trying to illustrate variable data about the host susceptibility, diseases, epidemiology, virulence factors, antibiotic resistance, treatment, and control of MRSA infection.