Simvastatin enhances bone formation around titanium implants in rat tibiae
Simvastatin enhances bone formation around titanium implants in rat tibiae
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DOI：
10.1111/j.1365-2842.2009.02011.x
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发表时间：
2010-02-01
影响因子：
2.9
通讯作者：
Koyano, K.
中科院分区：
文献类型：
--
作者：
Ayukawa, Y.;Ogino, Y.;Koyano, K.
他汀类药物是降低胆固醇的药物，据报道可以促进骨形成。本研究旨在探讨辛伐他汀对钛种植体周围骨形成的促进作用。30周龄的雌性大鼠在两个胫骨中接受纯钛植入物。动物每天腹腔注射0、0.125、1、5或10 mg/kg辛伐他汀。30天后，处死动物，制备标本。测量种植体的骨接触率、髓腔骨密度和皮质骨百分比。还使用安乐死时采集的血清测量骨转换标志物。在0、0、125和1 mg kg（-1）组的髓管中观察到少量骨。相比之下，在5和10 mg kg（-1）组中，较厚的骨小梁丰富。组织计量学观察显示，两组的骨接触率和骨密度均显著高于其他组（ANOVA，P <0.01）。然而，两组间皮质骨百分比无显著差异。血清化学显示，他汀类药物增加骨形成标志物和减少骨吸收标志物。总之，尽管与高胆固醇血症患者使用的剂量相当的剂量无效，但5 mg kg（-1）或更高剂量的辛伐他汀可增加钛周围的髓骨形成。相比之下，辛伐他汀对既存皮质骨无影响。
Statins are cholesterol-lowering drugs that have been reported to promote bone formation. The purpose of this study was to investigate the effect of simvastatin on the enhancement of bone formation around titanium implants. Thirty-week-old female rats received pure titanium implants in both tibiae. The animals were intra-peritoneally administered 0, 0.125, 1, 5 or 10 mg kg(-1) of simvastatin daily. After 30 days, the animals were sacrificed, and specimens were prepared. The bone contact ratio of the implant, bone density in the medullary canal and percentage of cortical bone were obtained. Markers for bone turnover were also measured using sera collected at the time of euthanasia. In the medullary canal, a scanty amount of bone was observed in the 0, 0 125 and 1 mg kg(-1) groups. In contrast, in both the 5 and 10 mg kg(-1) groups, thicker bone trabeculae were abundant. Histometric observations showed that the bone contact ratio and the bone density of both groups were significantly greater than those of the other groups ( ANOVA, P < 0.01). However, no significant difference in the percentage of cortical bone was found between groups. Serum chemistry showed that statin increased bone formation markers and decreased bone resorption markers. In conclusion, although the dose equivalent to that used in human patients with hypercholesterolemia was not effective, a simvastatin dose of 5 mg kg(-1) or higher increased medullary bone formation around the titanium. In contrast, no effect of simvastatin on pre-existing cortical bone was indicated.