Review: Proteins with repeated sequence - Structural prediction and modeling
Review: Proteins with repeated sequence - Structural prediction and modeling
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DOI：
10.1006/jsbi.2000.4328
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发表时间：
2001-05-01
影响因子：
3
通讯作者：
Kajava, AV
中科院分区：
文献类型：
--
作者：
Kajava, AV
讨论了氨基酸序列与具有内部重复的蛋白质三维结构之间的关系。特别是，描述了氨基酸组成和折叠成独特结构的能力之间的相关性，以及基于重复长度的结构分类。该分析提出了可用于含重复蛋白质的结构预测的规则。该论文的重点是重复长度在 5 到 40 个残基之间的螺线管样蛋白质的预测和建模。根据最近解决的相关分子的结构，检查了富含亮氨酸的重复蛋白和具有五肽重复的细菌蛋白的模型。 (C) 2001 年学术出版社。
The relationship between the amino acid sequence and the three-dimensional structure of proteins with internal repeats is discussed. In particular, correlations between the amino acid composition and the ability to fold in a unique structure, as well as classification of the structures based on their repeat length, are described. This analysis suggests rules that can be used for the structural prediction of repeat-containing proteins. The paper is focused on prediction and modeling of solenoid-like proteins with the repeat length ranging between 5 and 40 residues. The models of leucine-rich repeat proteins and bacterial proteins with pentapeptide repeats are examined in light of the recently solved structures of the related molecules. (C) 2001 Academic Press.