Highly heterogeneous residual malaria risk in western Thailand
Highly heterogeneous residual malaria risk in western Thailand
复制标题
DOI：
10.1016/j.ijpara.2019.01.004
复制
发表时间：
2019-05-01
影响因子：
4
通讯作者：
Sattabongkot, Jetsumon
中科院分区：
文献类型：
--
作者：
Nguitragool, Wang;Karl, Stephan;Sattabongkot, Jetsumon
在过去几十年里，泰国的疟疾负担已大幅下降。现在大多数感染来自国家边境地区。在这些地区，无症状感染的流行率仍然很高，这对国家疟疾消除计划构成了挑战。为了确定泰国西部疟疾感染的流行病学参数和危险因素，我们在泰缅边境的北碧府和拉差武里省开展了一项队列研究。在2013年5月至2014年6月期间，每4周对999名当地参与者的血液样本进行疟疾感染检查。恶性疟原虫和间日疟原虫的流行率采用定量PCR （qPCR）测定，呈现季节性变化，间日疟原虫的流行率为1.7% ~ 4.2%，恶性疟原虫的流行率为0% ~ 1.3%。90%的感染者是无症状的。通过微卫星基因分型估计，年血期感染分子力（molFOB）为间日疟原虫每年新增感染0.24例，恶性疟原虫每年新增感染0.02例。感染的分布具有异质性，即绝大多数感染（约80%）发生在少数个体中(
Over the past decades, the malaria burden in Thailand has substantially declined. Most infections now originate from the national border regions. In these areas, the prevalence of asymptomatic infections is still substantial and poses a challenge for the national malaria elimination program. To determine epidemiological parameters as well as risk factors for malaria infection in western Thailand, we carried out a cohort study in Kanchanaburi and Ratchaburi provinces on the Thailand-Myanmar border. Blood samples from 999 local participants were examined for malaria infection every 4 weeks between May 2013 and Jun 2014. Prevalence of Plasmodium falciparum and Plasmodium vivax was determined by quantitative PCR (qPCR) and showed a seasonal variation with values fluctuating from 1.7% to 4.2% for P. vivax and 0% to 1.3% for P. falciparum. Ninety percent of infections were asymptomatic. The annual molecular force of blood-stage infection (molFOB) was estimated by microsatellite genotyping to be 0.24 new infections per person-year for P. vivax and 0.02 new infections per person-year for P. falciparum. The distribution of infections was heterogenous, that is, the vast majority of infections (>80%) were found in a small number of individuals (