Biological responses to silicon and nitrogen-rich PVD silicon nitride coatings
Biological responses to silicon and nitrogen-rich PVD silicon nitride coatings
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DOI：
10.1016/j.mtchem.2020.100404
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发表时间：
2021-03
影响因子：
7.3
通讯作者：
E. Marin;F. Boschetto;M. Zanocco;W. Zhu;T. Adachi;N. Kanamura;T. Yamamoto;B. McEntire;E. Jones;C. Powell;J. Hendry;R. Bock;B. Bal;G. Pezzotti
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文献类型：
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作者：
E. Marin;F. Boschetto;M. Zanocco;W. Zhu;T. Adachi;N. Kanamura;T. Yamamoto;B. McEntire;E. Jones;C. Powell;J. Hendry;R. Bock;B. Bal;G. Pezzotti
大多数结构生物陶瓷是由金属氧化物如氧化铝和氧化锆组成的。它们通常被认为是完全生物惰性的，但一种非氧化物陶瓷，氮化硅，在具有生物活性的同时达到了同等水平的机械可靠性。氮化硅不仅能刺激细胞增殖，而且具有抗致病性，对革兰氏阳性和革兰氏阴性细菌、真菌和病毒都有明显的疗效。在这项工作中，三种不同Si:N比（富硅、化学计量和富氮）的物理气相沉积涂层被沉积在镜面抛光的硅玻璃衬底上。采用光谱学和显微技术对涂层进行了表征，并进行了玻璃体测试。coliand KUSA-A1间充质细胞。结果表明，富氮sixny对大肠杆菌具有较强的抗菌作用。coliand有助于细胞增殖，而富含硅的sixny刺激骨组织的产生，具有更高的矿化指数和质量。这些结果表明，SixNy的生物特性可以通过仔细调整其表面化学来优化特定应用。
Most structural bioceramics are comprised of metallic oxides such as alumina and zirconia. They are generally considered to be completely bioinert, but a non-oxide ceramic, silicon nitride, achieves equivalent levels of mechanical reliability while being bioactive. Silicon nitride can not only stimulate cellular proliferation but it is also antipathogenic with demonstrated efficacy against Gram-positive and Gram-negative bacteria, fungi, and viruses. In this work, three physical vapor deposition coatings with different Si:N ratios (silicon-rich, stoichiometric, and nitrogen-rich) were deposited on mirror-polished silica glass substrates. The coatings were characterized by spectroscopic and microscopic techniques and testedin vitroagainstE. coliand KUSA-A1 mesenchymal cells. Results showed that nitrogen-enriched SixNyhas a strong antibacterial effect againstE. coliand contributes to cellular proliferation while silicon-enriched SixNystimulates the production of bone tissue, with higher indexes for mineralization and quality. These results suggest that SixNy's biological properties can be optimized for specific applications by carefully tuning its surface chemistry.