Effect of smoking on arterial stiffness and pulse pressure amplification
Effect of smoking on arterial stiffness and pulse pressure amplification
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DOI：
10.1161/01.hyp.0000047464.66901.60
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发表时间：
2003-01-01
期刊：
影响因子：
8.3
通讯作者：
Feely, J
中科院分区：
文献类型：
--
作者：
Mahmud, A;Feely, J
吸烟者的肱动脉压力波形异常，但吸烟对吸烟者和非吸烟者，特别是年轻人群的主动脉压力波形的影响尚不清楚。我们比较了吸烟对 185 名健康年轻吸烟者和非吸烟者大动脉特性的急性和慢性影响（平均值 +/- SD，22 +/- 5 岁）。我们将 41 名长期吸烟者的年龄、身高、体重和性别与 116 名不吸烟者进行了匹配。增强指数是主动脉中动脉波反射的量度，通过压平眼压计（Sphygmocor）测量。我们还比较了 28 名受试者（11 名长期吸烟者）在吸 1 支烟（尼古丁含量，1.2 毫克）之前和之后 15 分钟内的增强指数、主动脉脉搏波速度 (Complior) 和血压。尽管肱动脉血压没有差异，但主动脉收缩压（101 +/- 8 与 97 +/- 9 mmHg）和增强指数（0.7 +/- 13 与 -5.7 +/- 14）较高（P
The brachial artery pressure waveform is abnormal in smokers, but the effect of smoking on the aortic pressure waveform in both smokers and nonsmokers, particularly in the younger population, is unknown. We compared the acute and chronic effects of smoking on large-artery properties in 185 healthy young smokers and nonsmokers (mean +/- SD, 22 +/- 5 years). We matched 41 chronic smokers for age, height, weight, and gender with 116 nonsmokers. The augmentation index, a measure of arterial wave reflection in the aorta, was measured by applanation tonometry (Sphygmocor). We also compared augmentation index, aortic pulse wave velocity (Complior), and blood pressure in 28 subjects (11 chronic smokers) before and for 15 minutes after smoking 1 cigarette (nicotine content, 1.2 mg). Although brachial blood pressure was not different, the aortic systolic blood pressure (101 +/- 8 versus 97 +/- 9 mmHg) and augmentation index (0.7 +/- 13 versus -5.7 +/- 14) were higher (P