Development and validation of computational models for mammalian circadian oscillators.
Development and validation of computational models for mammalian circadian oscillators.
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DOI：
10.1089/153623103322637698
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发表时间：
2003-12-01
期刊：
影响因子：
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通讯作者：
Weaver, David R.
中科院分区：
文献类型：
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作者：
Forger, Daniel B.;Dean, Dennis A., II;Weaver, David R.
昼夜节律是一种内源性节律，周期长度约为24小时。起搏器结构中特定蛋白质的节律性产生是这些生理和行为节律的基础。先前对分子昼夜节律振荡器的数学建模工作主要集中在果蝇上。最近，我们对哺乳动物昼夜节律的分子基础的理解取得了很大进展。哺乳动物昼夜节律振荡器的数学模型需要拼凑各种数据，预测实验结果，并帮助我们理解整个时钟。我们的目标是开发哺乳动物昼夜节律振荡器的数学模型，从这些模型中生成和测试预测，收集模型开发所需参数的信息，将分子模型与光和节律对人类表现影响的现有模型集成，并使模型可在BioSpice中使用，以便于一般社区使用。建立了两种新的哺乳动物模型，并对实验数据进行了总结。这些研究有可能导致重置生物钟的新策略。操纵生物钟可以通过促进警觉性和生理同步来优化性能。
Circadian rhythms are endogenous rhythms with a cycle length of approximately 24 h. Rhythmic production of specific proteins within pacemaker structures is the basis for these physiological and behavioral rhythms. Prior work on mathematical modeling of molecular circadian oscillators has focused on the fruit fly, Drosophila melanogaster. Recently, great advances have been made in our understanding of the molecular basis of circadian rhythms in mammals. Mathematical models of the mammalian circadian oscillator are needed to piece together diverse data, predict experimental results, and help us understand the clock as a whole. Our objectives are to develop mathematical models of the mammalian circadian oscillator, generate and test predictions from these models, gather information on the parameters needed for model development, integrate the molecular model with an existing model of the influence of light and rhythmicity on human performance, and make models available in BioSpice so that they can be easily used by the general community. Two new mammalian models have been developed, and experimental data are summarized. These studies have the potential to lead to new strategies for resetting the circadian clock. Manipulations of the circadian clock can be used to optimize performance by promoting alertness and physiological synchronization.