Direct interaction between nerves and mast cells mediated by the SgIGSF/SynCAM adhesion molecule
Direct interaction between nerves and mast cells mediated by the SgIGSF/SynCAM adhesion molecule
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DOI：
10.1254/jphs.cpj06014x
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发表时间：
2006-09-01
影响因子：
3.5
通讯作者：
Oonuma, Junko
中科院分区：
文献类型：
--
作者：
Ito, Akihiko;Oonuma, Junko
到目前为止，越来越多的证据表明，神经系统和免疫系统之间的串扰在各种疾病的病理生理中起着关键作用。神经与肥大细胞之间的相互作用作为神经免疫系统的一种典型表现，已被广泛研究。在解剖学上，肥大细胞通常位于靠近神经的位置。功能上，两个细胞以双向方式相互通信。神经释放的P物质和肥大细胞的蛋白酶和细胞因子已被证明是这种通讯的重要介质。另一方面，参与神经和肥大细胞之间膜间接触的分子在很大程度上是未知的。2003年，两种细胞被发现表达相同的粘附分子，命名为SynCAM（突触细胞粘附分子）或SgIGSF（生精免疫球蛋白超家族）。由于SgIGSF/SynCAM是同源结合，我们在体外研究了其参与神经肥大细胞相互作用。颈上神经节沿神经突表达SgIGSF/SynCAM。缺乏SgIGSF/SynCAM的肥大细胞与这些神经突的粘附较差，这通过SgIGSF/SynCAM的异位表达而正常化。此外，表达SgIGSF/ syncam的肥大细胞与神经突的沟通能力更强。对黏附分子依赖性相互作用的进一步了解有望为神经免疫串扰领域开辟一条新的途径。
Accumulating evidence has so far indicated that cross-talk between the nervous and immune systems plays a pivotal role in the pathophysiology of various diseases. As a prototypic demonstration of neuro-immune systems, the interaction between nerves and mast cells has been examined intensively. Anatomically, mast cells are often located in close proximity to nerves. Functionally, both cells communicate with each other in a bi-directional manner. Substance P released from nerves and proteases and cytokines from mast cells have proved to be important mediators in such communication. On the other hand, the molecules involved in membrane-membrane contacts between nerves and mast cells were largely unknown. In 2003, both cells were found to express the identical adhesion molecule, named SynCAM (synaptic cell adhesion molecule) or SgIGSF (spermatogenic immunoglobulin superfamily). Since SgIGSF/SynCAM binds homophilically, its involvement in nerve-mast cell interaction was examined in vitro. Superior cervical ganglia expressed SgIGSF/SynCAM along their neurites. Adhesion to these neurites of mast cells lacking SgIGSF/SynCAM was poor, and this was normalized by ectopic expression of SgIGSF/SynCAM. Moreover, SgIGSF/SynCAM-expressing mast cells were more competent in communicating with the neurites. Further understanding of the adhesion molecule-dependent interaction will be expected to open a new avenue in the field of neuro-immune crosstalk.