Steric stabilisation of self-assembled cubic lyotropic liquid crystalline nanoparticles: high throughput evaluation of triblock polyethylene oxide-polypropylene oxide-polyethylene oxide copolymers
Steric stabilisation of self-assembled cubic lyotropic liquid crystalline nanoparticles: high throughput evaluation of triblock polyethylene oxide-polypropylene oxide-polyethylene oxide copolymers
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DOI：
10.1039/c1sm05181d
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发表时间：
2011-01-01
期刊：
影响因子：
3.4
通讯作者：
Drummond, Calum J.
中科院分区：
文献类型：
--
作者：
Chong, Josephine Y. T.;Mulet, Xavier;Drummond, Calum J.
纳米结构立方溶致液晶胶体颗粒（Cubosomes (TM)）在药物和生物医学显像剂封装系统等应用中受到关注。随着时间的推移保持这些纳米颗粒的稳定性和完整性对于它们的储存和应用至关重要。众所周知，三嵌段聚环氧乙烷-聚环氧丙烷-聚环氧乙烷 (PEO-PPO-PEO) 共聚物 Pluronic F127 为非层状溶致液晶颗粒的聚集提供空间屏障。然而，很少有其他稳定剂用于这些系统的报道。使用高通量方法制备和表征单油酸甘油酯和植烷三醇的分散体，评估了各种三嵌段 PEO-PPO-PEO 共聚物 (Pluronics) 的性能，以实现立方体的最佳稳定性。结果表明，作为基于单油酸酯的纳米结构颗粒的稳定剂，Pluronic F108 优于 Pluronic F127，因为它保留了颗粒双金刚石反双连续立方相内部结构的完整性，同时保持了胶体稳定性。
Nanostructured cubic lyotropic liquid crystalline colloidal particles (Cubosomes (TM)) are of interest for applications such as drug and biomedical imaging agent encapsulation systems. Maintaining the stability and integrity of these nanoparticles over time is essential for their storage and application. It is well known that the triblock polyethylene oxide-polypropylene oxide-polyethylene oxide (PEO-PPO-PEO) copolymer, Pluronic F127, imparts a steric barrier to aggregation of non-lamellar lyotropic liquid crystalline particles. However, few other stabilisers have been reported for these systems. Using high throughput methodologies to prepare and characterise dispersions of monoolein and phytantriol, the performance of a wide range of triblock PEO-PPO-PEO copolymers (Pluronics) was evaluated for optimal stabilisation of cubosomes. It is shown that Pluronic F108 is superior to Pluronic F127 as a stabiliser of monoolein based nanostructured particles, as it preserves the integrity of the double diamond inverse bicontinuous cubic phase internal structure of the particles, whilst maintaining colloidal stability.