SOLVENT EXPOSURE, ALCOHOL-CONSUMPTION AND LIVER-INJURY IN WORKERS MANUFACTURING PAINT
SOLVENT EXPOSURE, ALCOHOL-CONSUMPTION AND LIVER-INJURY IN WORKERS MANUFACTURING PAINT
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DOI：
10.5271/sjweh.1478
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发表时间：
1993-08-01
影响因子：
6.3
通讯作者：
MYERS, J
中科院分区：
文献类型：
--
作者：
REES, D;SODERLUND, N;MYERS, J
在89名南非油漆制造商中检查了肝酶活性，这些油漆制造商目前暴露于相当低水平的有机溶剂混合物中。然而，对许多人来说，接触的时间很长。58名工人（65%）至少有一种酶值高于参考上限。46%的工人γ谷氨酰转移酶（gammaGT）活性升高，52%的工人天冬氨酸转氨酶（ASAT）活性升高。在高和低溶剂暴露工人之间的比较中，γ GT和ASAT值在最暴露组中较高（例如，γ GT平均值为108对69 U。l-1，P>0.05）。调整酒精消耗和体重指数的混杂因素，消除了暴露引起的差异。得出的结论是，所使用的肝损伤指标并未证明溶剂引起的肝损伤，但过量饮酒是一个重要因素。
Liver enzyme activity was examined in 89 South African paint makers currently exposed to a mixture of organic solvents at fairly low levels. However, the duration of exposure was substantial for many. Fifty-eight workers (65%) had at least one enzyme value above the upper reference limit. Gamma glutamyl transferase (gammaGT) activity was elevated in 46% of the workers and aspartate aminotransferase (ASAT) in 52%. In a comparison between workers with high and low solvent exposure, the gammaGT and ASAT values were higher in the most exposed group (eg, gammaGT mean 108 versus 69 U . l-1, P>0.05). Adjustment for confounding by alcohol consumption and body mass index eliminated the differences due to exposure. It was concluded that the measures of liver injury used did not demonstrate solvent-induced hepatic damage but that excessive alcohol consumption was an important factor.