Analysis of one million base pairs of Neanderthal DNA
Analysis of one million base pairs of Neanderthal DNA
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DOI：
10.1038/nature05336
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发表时间：
2006-11-16
期刊：
影响因子：
64.8
通讯作者：
Paeaebo, Svante
中科院分区：
文献类型：
--
作者：
Green, Richard E.;Krause, Johannes;Paeaebo, Svante
尼安德特人是与当代人类关系最密切的灭绝的原始人类群体，因此他们的基因组提供了一个独特的机会来识别解剖学上完全现代人类特有的遗传变化。我们发现了一个有38,000年历史的尼安德特人化石，它特别没有受到现代人类DNA的污染。从该化石中提取的DNA的直接高通量测序迄今已产生了超过一百万个碱基对的类人猿核DNA序列。与人类和黑猩猩基因组的比较显示，现代人类和尼安德特人的DNA序列平均在大约50万年前出现分歧。现有的技术和化石资源现在足以启动尼安德特人基因组测序工作。
Neanderthals are the extinct hominid group most closely related to contemporary humans, so their genome offers a unique opportunity to identify genetic changes specific to anatomically fully modern humans. We have identified a 38,000- year- old Neanderthal fossil that is exceptionally free of contamination from modern human DNA. Direct high- throughput sequencing of a DNA extract from this fossil has thus far yielded over one million base pairs of hominoid nuclear DNA sequences. Comparison with the human and chimpanzee genomes reveals that modern human and Neanderthal DNA sequences diverged on average about 500,000 years ago. Existing technology and fossil resources are now sufficient to initiate a Neanderthal genome- sequencing effort.