Fungus-mediated synthesis of silver nanoparticles and their activity against pathogenic fungi in combination with fluconazole
Fungus-mediated synthesis of silver nanoparticles and their activity against pathogenic fungi in combination with fluconazole
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DOI：
10.1016/j.nano.2009.06.005
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发表时间：
2009-12-01
影响因子：
5.4
通讯作者：
Rai, Mahendra
中科院分区：
文献类型：
--
作者：
Gajbhiye, Monali;Kesharwani, Jayendra;Rai, Mahendra
银纳米颗粒(Ag-NPs)具有抑制和杀菌作用。真菌感染的耐药性是近年来出现的，是一个主要的健康问题。在这里，我们报告了一种常见的真菌--交链孢霉的胞外生物合成纳米银。此外，在本研究中，还评估了这些纳米颗粒在提高氟康唑对团花镰刀菌、草腐病菌、半架构镰刀菌、木霉菌和白色念珠菌的抗真菌活性方面的作用。在银纳米粒子存在下，氟康唑对供试真菌的抗真菌活性增强。氟康唑与银纳米粒联合使用对白色念珠菌的抑制作用最强，其次是团状念珠菌和木霉，折叠面积增加幅度较小，而对草霉和半根癌的抑制作用不明显。氟康唑与银纳米粒联合用药对白色念珠菌的抑制作用最强，其次是团头状念珠菌和木霉。对草霉和半乳镰刀菌的活性没有明显的增强作用。(C)2009 Elsevier Inc.保留所有权利。
Silver nanoparticles (Ag-NPs) are known to have inhibitory and bactericidal effects. Resistance of fungal infections has emerged in recent years and is a major health problem. Here, we report the extracellular biosynthesis of Ag-NPs using a common fungus, Alternaria alternata. Also in this study, these nanoparticles were evaluated for their part in increasing the antifungal activity of fluconazole against Phoma glomerata, Phoma herbarum, Fusarium semitectum, Trichoderma sp., and Candida albicans. The antifungal activity of fluconazole was enhanced against the test fungi in the presence of Ag-NPs. Fluconazole in combination with Ag-NPs showed the maximum inhibition against C. albicans, which was confirmed from the increase in fold area of inhibition, followed by P. glomerata and Trichoderma sp., which showed less increase in the fold area, whereas no significant enhancement of activity was found against P. herbarum and F. semitectum.From the Clinical Editor: The antifungal activity of fluconazole was enhanced in presence of silver nanoparticles against the test fungi. Fluconazole in combination with Ag-NPs showed the maximum inhibition against C. albicans, followed by P. glomerata and Trichoderma sp. No significant enhancement of activity was found against P. herbarum and F. semitectum. (C) 2009 Elsevier Inc. All rights reserved.